Small-scale mechanical testing: Applications to bone biomechanics and mechanobiology
Mechanical testing of biologic tissues requires flexible testing machines to accommodate a variety of testing needs. This paper will illustrate how a cost-effective testing platform was developed to accommodate a wide range of biomechanical testing applications including bone bending and torsion testing, soft tissue tensile testing and bone cell stimulation via fluid shear and substrate deformation. The goal is to demonstrate to the reader that unique issues arise when testing biologic tissues such as controlling for environment and maintaining specimen viability, but with proper care relatively reproducible and accurate testing results can be obtained with a simple, multi-purpose platform.
KeywordsTorsion Testing Substrate Deformation Parallel Plate Flow Chamber Linear Slide Biomechanical Engineer
Unable to display preview. Download preview PDF.
- 2.Currey JD. Bones: Structure and mechanics. Princeton, NJ: Princeton University Press; 2002.Google Scholar
- 3.Cowin SC, ed. Bone Mechanics Handbook, 2nd ed. Boca Raton, FL: CRC Press; 2001.Google Scholar
- 4.An YH, Draughn RA eds. Mechanical testing of bone and the bone-implant interface. Boca Raton, FL: CRC Press; 2000.Google Scholar
- 7.Saunders MM, Burger RB, Kalantari B, Nichols AD, Witman C. Development of a cost-effective torsional unit for small-scale biomechanical testing. Med Engr Phys (in press), 2010.Google Scholar
- 19.Ott SM. Website link: http://depts.washington.edu/bonebio/ASBMRed/growth.html (Bone remodeling)
- 22.Buhl KM, Jacobs CR, Turner RT, Evans GL, Farrell PA, Donahue HJ. Aged bone displays an increased responsiveness to low-intensity resistance exercise. J Appl Physiol 90:1359–1364, 2001.Google Scholar
- 26.Saunders MM, Simmerman LA, Reed GL, Sharkey NA, Taylor AF. Biomimetic bone mechanotransduction modeling in neonatal rat femur organ cultures: Structural verification of proof of concept. Biomech Model Mechanobiol, 2010. (published online 2/19/10).Google Scholar
- 27.Van Sickels J. College of Dentistry, University of Kentucky. (personal correspondence), 2009.Google Scholar