Abstract
The debate over hormone replacement therapy (HRT) has been one of the biggest health discussions in recent history. Professional groups and nonprofits, such as the American College of Physicians and the American Heart Association, gave HRT their stamp of approval 15 years ago. Studies indicated that HRT was protective against osteoporosis and heart disease. HRT became big business, with millions upon millions of prescriptions filled each year. However, in 1998, the Heart and Estrogen-Progestin Replacement Study demonstrated increased risk of heart attack among women with heart disease taking HRT, and in 2002 the Women’s Health Initiative showed increased risk for breast cancer, heart disease, and stroke, among other ailments, for women on HRT. Why were there inconsistencies in the study results?
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© 2011 Springer Science+Business Media, LLC
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Rose, S., van der Laan, M.J. (2011). The Open Problem. In: Targeted Learning. Springer Series in Statistics. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9782-1_1
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DOI: https://doi.org/10.1007/978-1-4419-9782-1_1
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