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Targeted Drug Delivery Through the Respiratory System: Molecular Control on Lung Absorption and Disposition

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Controlled Pulmonary Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Drug delivery through the respiratory system is important for both locally and systemically acting drugs delivered as inhalation aerosols. This chapter reviews our current knowledge of diffusion and transporter controls on lung epithelial absorption of inhaled drug molecules. Moreover, competing nonabsorptive clearance via local metabolism, phagocytosis, and mucociliary escalator, and its impact and control on lung absorption will be also discussed.

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Authors and Affiliations

  1. Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, 410 N 12th Street, 980533, Richmond, VA, 23298-0533, USA

    Masahiro Sakagami

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  1. Masahiro Sakagami
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  2. Mark Gumbleton
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Correspondence to Masahiro Sakagami .

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Editors and Affiliations

  1. , Pharmaceutics Division - PHR 4.214, University of Texas, University Station 1, Austin, 78712, USA

    Hugh D.C. Smyth

  2. Eshelman School of Pharmacy, Division of Molecular Pharmaceutics, University of North Carolina, Chapel Hill, 27599, North Carolina, USA

    Anthony J. Hickey

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Sakagami, M., Gumbleton, M. (2011). Targeted Drug Delivery Through the Respiratory System: Molecular Control on Lung Absorption and Disposition. In: Smyth, H., Hickey, A. (eds) Controlled Pulmonary Drug Delivery. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9745-6_6

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