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Nanoparticles for Pulmonary Delivery

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Controlled Pulmonary Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

This chapter aims to provide a rational for the use of nanoparticles in pulmonary delivery as well as an overview of strategies and physiological implications of nanoparticle delivery to the lungs. Formulation aspects of nanoparticle systems in the form of liquid dispersions and inhaled dry powders are also reviewed. The chapter also addresses the expanse of lung toxicology research surrounding the inhalation of nanoparticulate pollutants present in the environment. The observations of the adsorption, distribution, metabolism, and excretion (ADME) of these insoluble nanoparticles may lead to a greater understanding of biological interactions of inhaled drug nanoparticles and their ultimate site of action.

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Authors and Affiliations

  1. Division of Pharmaceutics, College of Pharmacy, University of Texas at Austin, Mailstop A1920, Austin, TX, 78712, USA

    Robert O. Williams III

Authors
  1. Alan B. Watts
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  2. Robert O. Williams III
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Correspondence to Robert O. Williams III .

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  1. , Pharmaceutics Division - PHR 4.214, University of Texas, University Station 1, Austin, 78712, USA

    Hugh D.C. Smyth

  2. Eshelman School of Pharmacy, Division of Molecular Pharmaceutics, University of North Carolina, Chapel Hill, 27599, North Carolina, USA

    Anthony J. Hickey

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© 2011 Controlled Release Society

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Watts, A.B., Williams, R.O. (2011). Nanoparticles for Pulmonary Delivery. In: Smyth, H., Hickey, A. (eds) Controlled Pulmonary Drug Delivery. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9745-6_15

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