Design of Fermentation Processes

  • John Villadsen
  • Jens Nielsen
  • Gunnar Lidén


In previous chapters, the stoichiometry of bioreactions has been investigated, and it was shown that how steady-state rates could be measured for many reaction components. In Chaps. 3 and 4, the extent of the bioreaction was determined as a function of the reaction conditions, in particular, the feed composition, the redox level, and pH. In Chap. 5, the black box model for a bioreaction was greatly expanded to include a sub-set of the almost infinite number of reactions in the metabolic network. Finally, in Chaps. 6 and 7, the chemical reaction, first in enzyme reactions and then in cell cultivations, was treated by the same tools as are used in “ordinary” chemical reactions: The reaction rate was described as a function of the concentrations of reactants and afterwards included in mass balances.


Dilution Rate Stir Tank Reactor Loop Reactor Unstable Steady State Plug Flow Reactor 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Chemical and Biochemical EngineeringTechnical University of Denmark (DTU)LyngbyDenmark
  2. 2.Systems BiologyChalmers University of TechnologyGothenburgSweden
  3. 3.Department of Chemical EngineeringLund UniversityLundSweden

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