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Iron-Chelating Therapy in Stroke

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Metal Ion in Stroke

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

Abstract

Extensive preclinical and clinical investigations indicate that iron, ­mobilized from serum, body tissues, and brain, causes neurotoxic effects in cerebral ischemia and hemorrhage. Iron plays a role in neuronal injury by catalyzing oxidative reactions that yield highly reactive toxic hydroxyl radicals leading to oxidative stress and cell death, activating lipid peroxidation, and exacerbating excitotoxicity. Deferoxamine (DFO), a powerful iron chelator, has been demonstrated in experimental stroke models as an effective neuroprotective agent by multiple and diverse mechanisms, principally by limitation of iron-mediated neurotoxicity but also by non-iron-mediated effects. This chapter reviews the experimental and clinical data existing about the neuroprotective role of iron chelators, especially DFO, in brain ischemia and hemorrhage.

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Authors and Affiliations

  1. Stroke Unit and Experimental Neurovascular Laboratory, Neurosciences Department, Hospital Germans Trias i Pujol, Carretera del Canyet, s/n, Badalona, 08160, Barcelona, Spain

    Mónica Millán MD, PhD, Natalia Pérez de la Ossa MD & Teresa Gasull PhD

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  1. Mónica Millán MD, PhD
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  2. Natalia Pérez de la Ossa MD
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  3. Teresa Gasull PhD
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Correspondence to Mónica Millán MD, PhD .

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Editors and Affiliations

  1. , Department of Biomedical Sciences, Ohio University, 346 Irvine Hall, Athens, 45701, Ohio, USA

    Yang V. Li

  2. Loma Linda University, 11234 Anderson Street, Room 2562B, Loma Linda, 92354, California, USA

    John H. Zhang

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Millán, M., de la Ossa, N.P., Gasull, T. (2012). Iron-Chelating Therapy in Stroke. In: Li, Y., Zhang, J. (eds) Metal Ion in Stroke. Springer Series in Translational Stroke Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9663-3_14

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