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Implication of Oxidative Stress and “Labile Iron” in the Molecular Mechanisms of Ischemic Stroke

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Book cover Metal Ion in Stroke

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

Abstract

Strong experimental data support the notion that excessive generation of reactive free radicals takes place in the ischemic area following a stroke episode and that these radicals are responsible for a substantial part of brain injury. However, the exact biochemical mechanisms underlying brain cell damage remain elusive, thus hindering the attempts for development of effective therapeutic strategies. In this presentation, the molecular mechanisms of tissue damage in relation to temporal and spatial generation of “reactive oxygen species” are considered. The mechanisms of oxidant-mediated brain damage are discussed and the role of “labile iron” in this process is evaluated. Although oxygen based oxidants are generated during all phases, their sources and intensities as well as their temporal and spatial generation differ considerably among different phases in stroke. Based on the above ­considerations, it is proposed that administration of appropriate “labile iron” chelating agents, preferentially prior to reperfusion, might improve the efficacy of any therapeutic strategy.

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Acknowledgements

The authors would like to thank Drs. Panagiotis Korantzopoulos and Stilianos Kokkoris for critical reading of the manuscript and helpful comments.

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Authors and Affiliations

  1. Laboratory of Biological Chemistry, University of Ioannina Medical School, Ioannina, 45110, Greece

    Dimitrios Galaris & Natalia Kitsati

  2. Department of Neurology, University of Ioannina Medical School, Ioannina, 45110, Greece

    Sygkliti-Henrietta Pelidou

  3. Department of Anatomy, Histology and Embryology, University of Ioannina Medical School, Ioannina, 45110, Greece

    Alexandra Barbouti

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  1. Dimitrios Galaris
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  2. Natalia Kitsati
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  3. Sygkliti-Henrietta Pelidou
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  4. Alexandra Barbouti
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Correspondence to Dimitrios Galaris .

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Editors and Affiliations

  1. , Department of Biomedical Sciences, Ohio University, 346 Irvine Hall, Athens, 45701, Ohio, USA

    Yang V. Li

  2. Loma Linda University, 11234 Anderson Street, Room 2562B, Loma Linda, 92354, California, USA

    John H. Zhang

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Galaris, D., Kitsati, N., Pelidou, SH., Barbouti, A. (2012). Implication of Oxidative Stress and “Labile Iron” in the Molecular Mechanisms of Ischemic Stroke. In: Li, Y., Zhang, J. (eds) Metal Ion in Stroke. Springer Series in Translational Stroke Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9663-3_12

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