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Iron Neurotoxicity in Ischemic and Hemorrhagic Stroke

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Metal Ion in Stroke

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

Abstract

Disturbance of iron homeostasis in the brain plays an important pathogenic role in aggravating secondary neuronal injury and influencing recovery and functional outcome following cerebral ischemia or hemorrhage via several mechanisms including the release of redox-active iron, depletion of cellular energy stores, production of superoxide and hydroxyl radicals, and lipid peroxidation. We systematically review the currently available preclinical and clinical evidence supporting the role of iron-mediated toxicity in ischemic and hemorrhagic strokes, and its potential mechanisms. We also highlight the strategies being developed for the reduction of iron toxicity in stroke patients, and novel clinical therapeutic trials of iron-modifying agents in patients with ischemic and hemorrhagic strokes. Targeting iron toxicity as a treatment for stroke is an appealing and promising option. Future clinical studies are needed to translate a plethora of preclinical data into the clinical setting.

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Authors and Affiliations

  1. Stroke Division, Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Palmer 127, Boston, MA, 02215, USA

    Chih Ming Lin MD & Magdy Selim MD, PhD

  2. Department of Neurology, Cathay General Hospital, Hsinchu, Taiwan

    Chih Ming Lin MD

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  1. Chih Ming Lin MD
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  2. Magdy Selim MD, PhD
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Correspondence to Magdy Selim MD, PhD .

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Editors and Affiliations

  1. , Department of Biomedical Sciences, Ohio University, 346 Irvine Hall, Athens, 45701, Ohio, USA

    Yang V. Li

  2. Loma Linda University, 11234 Anderson Street, Room 2562B, Loma Linda, 92354, California, USA

    John H. Zhang

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Lin, C.M., Selim, M. (2012). Iron Neurotoxicity in Ischemic and Hemorrhagic Stroke. In: Li, Y., Zhang, J. (eds) Metal Ion in Stroke. Springer Series in Translational Stroke Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9663-3_11

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