Postextraction Considerations

  • Ivelisse Colón


After extracting APIs and components of interest from dosage form samples, the nature of the resulting sample extracts often requires additional pretreatment steps prior to quantitative analysis. This complexity is a direct result of the presence of excipients with different physical properties in the dosage forms. This chapter summarizes the factors that should be taken into consideration prior to the quantitative analysis of a pharmaceutical dosage form extract. Current strategies to overcome, troubleshoot, and minimize potential problems are also presented through the discussion of relevant case studies.


Ionic Liquid Derivatization Procedure Pharmaceutical Dosage Form Relative Centrifugal Force Undissolved Material 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Quality: CMC & QbDVertex Pharmaceuticals Inc.CambridgeUSA

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