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Nanomaterials for Immunosensors and Immunoassays

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NanoBiosensing

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

There is a continuously increasing demand for the specific and sensitive ­determination of trace amounts of analytes in complex matrices for various ­purposes. In this respect, immunoassays and immunosensors that rely on ­antibody–antigen binding provide a promising approach of analysis for their remarkable specificity and sensitivity. High specificity of immunoassays and immunosensors is achieved solely by the molecular recognition of target analytes by antibodies or antigens to form stable immunocomplexes. On the other hand, sensitivity depends on several factors, including the affinity of antibodies, the amount of immobilized immunological recognition elements, and the choice of transducer and signal probe. Therefore, the improvement of immunoassay and immunosensor performance mainly relies on the development of antibody preparation techniques, the improvement of immobilization and tagging methods, and the adoption of a high-performance transduction method.

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Authors and Affiliations

  1. Nanjing University, Nanjing, P.R. China

    Huangxian Ju

  2. World Precision Instruments, Inc., Sarasota, FL, USA

    Xueji Zhang

  3. University of Science & Technology, Beijing, P.R. China

    Xueji Zhang

  4. University of California, San Diego, CA, USA

    Joseph Wang

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  1. Huangxian Ju
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  2. Xueji Zhang
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  3. Joseph Wang
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Correspondence to Huangxian Ju .

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Ju, H., Zhang, X., Wang, J. (2011). Nanomaterials for Immunosensors and Immunoassays. In: NanoBiosensing. Biological and Medical Physics, Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9622-0_15

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