Kainate Receptor Modulation by Sodium and Chloride

  • Andrew J. R. PlestedEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 717)


The kainate-type glutamate receptor displays strong modulation by monovalent anions and cations. This modulation is independent of permeation of the ion channel. Instead, structural, computational and biophysical evidence shows that receptor activity is controlled by binding of sodium and chloride ions at sites that stabilize active dimers of glutamate binding domains. Modulation by monovalent ions is a surprisingly general property across ion channel families. However, evidence of a physiological role for ion-dependent effects on glutamate receptors is lacking, perhaps reflecting the adventitious use of ions as structural components of the kainate receptor.

“ergo, Hercules, vita humanior sine sale non quit degree […]” “Heaven known, a civilized life is impossible without salt” —Pliny the Elder, Natural History XXXI 88


AMPA Receptor Cation Site Anion Site Domoic Acid Dime Interface 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Landes Bioscience and Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Leibniz-Institut für Molekulare Pharmakologie (FMP)BerlinGermany

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