Skip to main content
SpringerLink
Log in
Book cover

Kainate Receptors pp 27–37Cite as

Localization and Functions of Kainate Receptors in the Basal Ganglia

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 717))

Abstract

Kainate receptors (KARs) are one of the three subtypes of ionotropic glutamate receptors in the CNS. These receptors are widely expressed pre- and postsynaptically throughout the brain. Thus, kainate receptor activation mediates a large variety of pre- and postsynaptic effects on either glutamatergic or GABAergic synaptic transmission. Although ionotropic functions for KAR have been described in multiple brain regions, there is considerable evidence from various CNS regions that KARs activation modulates GABA release through either G-protein dependent metabotropic pathway or secondary activation of G-protein coupled receptors. In the present chapter, we provide further evidence supporting that these two pathways are also involved in the modulation of GABA release in specific basal ganglia nuclei. Because of their more subtle effects on neurotransmisison regulation than other ionotropic glutamate receptors, KARs represent interesting targets for the future development of pharmacotherapy for basal ganglia diseases.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hollman M, Heinemann S. Cloned glutamate receptors. Annu Rev Neurosci 1994; 17:31–108.

    Article  Google Scholar 

  2. Bettler B, Mulle C. Neurotransmitter receptors IL AMPA and kainat ereceptors. Neuropharmacology 1995; 34:123–139.

    Article  PubMed  CAS  Google Scholar 

  3. Charara A, Blankstein E, Smith Y. Presynaptic kainate receptors in the monkey striatum. Neuroscience 1999; 91(4):1195–1200.

    Article  PubMed  CAS  Google Scholar 

  4. Lerma J, Paternain AV, Rodriguez-Moreno A et al. Molecular physiology of kainate receptors. Physiol Rev 2001; 81:971–998.

    PubMed  CAS  Google Scholar 

  5. Kieval JZ, Hubert GW, Charara A et al. Subcellular and subsynaptic localization of presynaptic and postsynaptic kainate receptor subunits in the monkey striatum. J Neurosci 2001; 21:8746–8757.

    PubMed  CAS  Google Scholar 

  6. Kullmann DM. Presynaptic kainate receptors in the hippocampus: slowly emerging from obscurity. Neuron 2001; 32:561–564.

    Article  PubMed  CAS  Google Scholar 

  7. Huettner JE. Kainate receptors and synaptic transmission. Prog in Neurobiol 2003; 70(5):387–407.

    Article  CAS  Google Scholar 

  8. Lerma J. Roles and rules of kainate receptors in synaptic transmission. Nat Rev Neurosci 2003; 4(6):481–495.

    Article  PubMed  CAS  Google Scholar 

  9. Jin X-T, Paré JF, Raju DV et al. Localization and function of pre and postsynaptic kainate receptors in the rat globus pallidus. Eur J Neurosci 2006; 23:374–386.

    Article  PubMed  Google Scholar 

  10. Melyan Z, Lancaster B, Wheal HV. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci 2004; 24:4530–4534.

    Article  PubMed  CAS  Google Scholar 

  11. Braga MFM, Aroniadou-Anderjaska V, Xie J et al. Bidirectional modulation of GABA release by presynaptic glutamate receptor 5 kainate receptors in the basolateral amygdala. J Neurosci 2003; 23(2):442–452.

    PubMed  CAS  Google Scholar 

  12. Cossart R, Tyzio R, Dinocourt C et al. Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal interneurons. Neuron 2001; 29(2):497–508.

    Article  PubMed  CAS  Google Scholar 

  13. Jin X-T, Smith Y. Activation of presynaptic kainate receptors suppresses GABAergic synaptic transmission in the globus pallidus. Neuroscience 2007; 149:338–349.

    Article  PubMed  CAS  Google Scholar 

  14. Smith Y, Charara A, Paquet M et al. Ionotropic and metabotropic GABA and glutamate receptors in primate basal ganglia. J Chem Neuroanat 2001; 22:13–42.

    Article  PubMed  CAS  Google Scholar 

  15. Bahn S, Volk B, Wisden W. Kainate receptor gene expression in the developing rat brain. J Neurosci 1994; l4(9):5525–5547.

    Google Scholar 

  16. Bischoff S, Barhanin J, Bettler B et al. Spatial distribution of kainate receptor subunit mRNA in the mouse basal ganglia and ventral mesencephalon. J Comp Neurol 1997; 379:541–562.

    Article  PubMed  CAS  Google Scholar 

  17. Chergui K, Bouron A, Normand E et al. Functional GluR6 kainate receptors in the striatum: indirect downregulation of synaptic transmission. J Neurosci 2000; 20(6):2175–2182.

    PubMed  CAS  Google Scholar 

  18. Crowder TL, Ariwodola OJ, Weiner JL. Kainate receptor activation potentiates GABAergic synaptic transmission in the nucleus accumbens core. Brain Res 2006; 73–82.

    Google Scholar 

  19. Koos T, Tepper J. Inhibittory control of neurostriatal projection neurons by GABAergic interneurons. Nat Neurosci 1999; 2:467–472.

    Article  PubMed  CAS  Google Scholar 

  20. Tepper JM, Bolam JR Functional diversity and specificity of neostriatal interneurons. Curr Opin Neurobio 2004; 14:685–692.

    Article  CAS  Google Scholar 

  21. Jaeger D, Kita H, Wilson CJ. Surround inhibition among projection neurons is week or nonexistent in the rat neostriatum. J Neurophysio 1994; 72:2555–2558.

    CAS  Google Scholar 

  22. Kita H, Kitai ST. Intracellular study of rat globus pallidus neurons: membrane properties and responses to neostriatal, subthalamic and nigral stimulation. Brain Res 1991; 564:296–305.

    Article  PubMed  CAS  Google Scholar 

  23. Gerfen CR. The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia. Annu Rev Neurosci 1992; 15:285–320.

    Article  PubMed  CAS  Google Scholar 

  24. Bevan MD, Booth PA, Eaton SA et al. Selective innervation of neostriatal interneurons by a subclass of neuron in the globus pallidus of the rat. J Neurosci 1998; 18:9438–9452.

    PubMed  CAS  Google Scholar 

  25. Smith Y, Bevan MD, Shink E et al. Microcircuitry of the direct and indirect pathways of the basal ganglia. Neuroscience 1998; 86:353–387.

    Article  PubMed  CAS  Google Scholar 

  26. Frerking M, Petersen CC, Nicoll RA. Mechanisms underlying kainate receptor-mediated disinhibition in the hippocampus. Proc Natl Acad Sci USA 1999; 96:12917–12922.

    Article  PubMed  CAS  Google Scholar 

  27. Kerchner GA, Wilding TJ, Li P et al. Presynaptic kainate receptors regulate spinal sensory transmission. J Neurosci 2001; 21:59–66.

    PubMed  CAS  Google Scholar 

  28. Hettinger BD, Lee A, Linden J et al. Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum. J Comp Neurol 2001; 431:331–346.

    Article  PubMed  CAS  Google Scholar 

  29. Bogenpohl JW, Pare JF, Smith Y. Subcellular localization of adenosine A2a receptors in the striatum and globus pallidus of monkey and rat. Soc Neurosci Abstr 2008; P–P056.

    Google Scholar 

  30. Kane-Jackson R, Smith Y Pre-synaptic kainate receptors in GABAergic and Glutamatergic axon terminals in the monkey globus pallidus. Neuroscience 2003; 120:285–289.

    Article  Google Scholar 

  31. Rodríguez-Moreno A, Lerma J. Kainate receptor modulation of GABA release involves a metabotropic function. Neuron 1998; 20:1211–1218.

    Article  PubMed  Google Scholar 

  32. Frerking M, Nicoll RA. Synaptic kainate receptors. Curr Opin Neurobiol 2000; 10:342–351.

    Article  PubMed  CAS  Google Scholar 

  33. Rodríguez-Moreno A, Sihra TS. Metabotropic actions of kainate receptors in the CNS. J Neurochem 2007; 103:2121–2135.

    Article  PubMed  Google Scholar 

  34. Rodríguez-Moreno A, Sihra TS. Kainate receptors with a metabotropic modus operandi. Trends Neurosci 2007; 30(12):630–637.

    Article  PubMed  Google Scholar 

  35. Nakamura M, Jang IS, Ishibashi H et al. Possible roles of kainate receptors on GABAergic nerve terminals projecting to rat substantia nigra dopaminergic neurons. J Neurophysiol 2003; 90:1662–1670.

    Article  PubMed  CAS  Google Scholar 

  36. Cunha RA, Malva JO, Ribeiro JA. Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal [2H] GABA release. FEBS Letters 2000; 469(2-3):159–162.

    Article  PubMed  CAS  Google Scholar 

  37. Rodriguez-Moreno A, Lopez-Garcia JC, Lerma J. Two populations of kainate receptors with separate signaling mechanisms in hippocampal interneurons. Proc Natl Acad Sci USA 2000; 97:1293–1298.

    Article  PubMed  CAS  Google Scholar 

  38. Melyan Z, Wheal HV, Lancaster B. Metabotropic-mediated kainate receptor regulation of IsAHP and excitability in pyramidal cells. Neuron 2002; 34(1):107–114.

    Article  PubMed  CAS  Google Scholar 

  39. Melyan Z, Lancaster B, Wheal HV. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci 2004; 24:4530–4534.

    Article  PubMed  CAS  Google Scholar 

  40. Lauri SE, Segerstrale M, Vesikansa A et al. Endogenous activation of kainate receptors regulates glutamate release and network activity in the developing hippocampus. J Neurosci 2005; 25:4473–4484.

    Article  PubMed  CAS  Google Scholar 

  41. Petralia RS, Wang YX, Wenthold RJ. Histological and ultrastructural localization of the kainat receptor subunits, KA2 and GluR6/7, in the rat nervous system using selective antipeptide antibodies. J Comp Neurol 1994; 349:85–110.

    Article  PubMed  CAS  Google Scholar 

  42. Rodriguez-Moreno A, Herreras O, Lerma J. Kainate receptors presynaptic ally downregulate GABAergic inhibition in the rat hippocampus. Neuron 1997; 19:893–901.

    Article  PubMed  CAS  Google Scholar 

  43. Maingret F, Lauri SE, Taira T et al. Profound regulation of neonatal CA1 rat hippocampal GABAergic transmission by functionally distinct kainate receptor populations. J Physiol 2005; 567:131–142.

    Article  PubMed  CAS  Google Scholar 

  44. Semyanov A, Kullmann DM. Kainate receptor-dependent axonal depolarization and action potential initiation in interneurons. Nature Neurosci 2001; 4:718–723.

    Article  PubMed  CAS  Google Scholar 

  45. Kang N, Jiang L, He W et al. Presynaptic inactivation of action potentials and postsynaptic inhibition of GABAA currents contribute to KA-induced disinhibition in CA1 pyramidal neurons. J Neurophysiol 2004; 92:873–882.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Neuroscience, Yerkes National Primate Research Center and Department of Neurology, Emory University, 954, Catewood Road Northeast, Atlanta, Georgia, 30322, USA

    Xiao-Tao Jin

Authors
  1. Xiao-Tao Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yoland Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xiao-Tao Jin .

Editor information

Editors and Affiliations

  1. Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Sevilla, Spain

    Antonio Rodríguez-Moreno PhD

  2. Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK

    Talvinder S. Sihra PhD

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Landes Bioscience and Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Jin, XT., Smith, Y. (2011). Localization and Functions of Kainate Receptors in the Basal Ganglia. In: Rodríguez-Moreno, A., Sihra, T.S. (eds) Kainate Receptors. Advances in Experimental Medicine and Biology, vol 717. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9557-5_3

Download citation

Publish with us

Policies and ethics

Search

Navigation