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Metabotropic Actions of Kainate Receptors in the Control of GABA Release

  • Talvinder S. SihraEmail author
  • Antonio Rodríguez-MorenoEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 717)

Abstract

Kainate receptors (KARs) are members of the family of ionotropic glutamate receptors (iGluRs) which also include NMDA and AMPA receptors. As ionotropic receptors, KARs have been characterized, pre and postsynaptically, in several brain regions. In this chapter we review evidence that suggests that KARs mediate some of their effects without invoking ion-fluxes. Beginning with seminal experiments described some ten years ago, when the notion of a metabotropic action of KAR was first posited in the modulation of GABA release from hippocampal interneurons, increasingly, there have been reports indicating that some KAR functions overtly depend on G-protein activation and involve the participation of intracellular signalling cascades. Thus, KAR activation instigates a cascade involving Gi/o, phospholipase C and protein kinase C to suppress the release of GABA and therefore underpins disinhibition of pyramidal cells in the CA1 region of the hippocampus. This type of metabotropic function of KARs in controlling GABA release represents an additional level of activity-dependent control of synaptic inhibition which is independent of any ionotropic activity of KARs.

Keywords

AMPA Receptor Pertussis Toxin Kainate Receptor Hippocampal Interneuron IPSC Amplitude 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Neuroscience, Physiology and PharmacologyUniversity College LondonLondonUK
  2. 2.Departamento de Fisiologfía, Anatomfía y Biología CelularUniversidad Pablo de OlavideSevillaSpain

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