Mast Cells, Angiogenesis and Cancer

  • Domenico Ribatti
  • Enrico Crivellato
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 716)


Mast cells (MCs) were first described by Paul Ehrlich 1 in his doctoral thesis. MCs have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites. As most tumors contain inflammatory cell infiltrates, which often include plentiful MCs, the question as to the possible contribution of MCs to tumor development has progressively been emerging. In this chapter, the specific involvement of MCs in tumor biology and tumor fate will be considered, with particular emphasis on the capacity of these cells to stimulate tumor growth by promoting angiogenesis and lymphangiogenesis. Data from experimental carcinogenesis and from different tumor settings in human pathology will be summarized. Information to be presented will suggest that MCs may serve as a novel therapeutic target for cancer treatment.


Mast Cell Malignant Pleural Mesothelioma Merkel Cell Carcinoma Mast Cell Density Spindle Cell Lipoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2011

Authors and Affiliations

  • Domenico Ribatti
    • 1
  • Enrico Crivellato
    • 2
  1. 1.Department of Human Anatomy and HistologyUniversity of Bari Medical SchoolPiazza Giulio Cesare BariItaly
  2. 2.Department of Medical and Morphological Reseach, Section of AnatomyUniversity of Udine Medical SchoolUdineItaly

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