Experimental Platforms for Assessing White Matter Pathophysiology in Stroke

  • Ken Arai
  • Loc-Duyen D. Pham
  • Eng H. Lo
Part of the Springer Series in Translational Stroke Research book series (SSTSR)


This chapter aims at summarizing current knowledge on experimental systems for analyzing the role of white matter injury relevant to stroke. In this chapter, we will provide a broad but brief survey of existing models at the cell, tissue, and whole-animal levels. Experimental approaches have recently allowed a better understanding of the molecular and cellular pathways underlying oligodendrocyte and oligodendrocyte precursor cell damage and demyelination. Since white matter damage is a clinically important part of stroke, a systematic utilization of these cell/tissue/whole-animal platforms related to white matter pathophysiology may eventually lead us to discover new targets for treating stroke.


White Matter Middle Cerebral Artery Occlusion White Matter Lesion White Matter Injury White Matter Damage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Acknowledgments and Funding

Supported in part by the National Institutes of Health, the American Heart Association, and the Deane Institute. Material including adapted figures for this chapter has been extensively drawn from previously published reviews including: Lo et al., Nat Rev Neurosci 2003; Lo, Nat Med 2008; Arai et al., FEBS J 2009; Arai and Lo, Exp Transl Stroke Med 2009; Arai and Lo, FEBS J 2009.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Neuroprotection Research LaboratoryMassachusetts General Hospital/Harvard Medical SchoolCharlestownUSA

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