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Experimental Platforms for Assessing White Matter Pathophysiology in Stroke

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Translational Stroke Research

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

This chapter aims at summarizing current knowledge on experimental systems for analyzing the role of white matter injury relevant to stroke. In this chapter, we will provide a broad but brief survey of existing models at the cell, tissue, and whole-animal levels. Experimental approaches have recently allowed a better understanding of the molecular and cellular pathways underlying oligodendrocyte and oligodendrocyte precursor cell damage and demyelination. Since white matter damage is a clinically important part of stroke, a systematic utilization of these cell/tissue/whole-animal platforms related to white matter pathophysiology may eventually lead us to discover new targets for treating stroke.

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Acknowledgments and Funding

Supported in part by the National Institutes of Health, the American Heart Association, and the Deane Institute. Material including adapted figures for this chapter has been extensively drawn from previously published reviews including: Lo et al., Nat Rev Neurosci 2003; Lo, Nat Med 2008; Arai et al., FEBS J 2009; Arai and Lo, Exp Transl Stroke Med 2009; Arai and Lo, FEBS J 2009.

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  1. Neuroprotection Research Laboratory, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, 02129, USA

    Ken Arai, Loc-Duyen D. Pham & Eng H. Lo

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Correspondence to Ken Arai .

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    Paul A. Lapchak

  2. Loma Linda University, 11234 Anderson Street, Room 2562B, Loma Linda, 92354, California, USA

    John H. Zhang

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Arai, K., Pham, LD.D., Lo, E.H. (2012). Experimental Platforms for Assessing White Matter Pathophysiology in Stroke. In: Lapchak, P., Zhang, J. (eds) Translational Stroke Research. Springer Series in Translational Stroke Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9530-8_3

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