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Iron as a Therapeutic Target in Intracerebral Hemorrhage: Preclinical Testing of Deferoxamine

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Book cover Translational Stroke Research

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality. Experimental studies have found that brain iron overload occurs after ICH and iron has a key role in ICH-induced brain injuiry. Deferoxamine, an iron chelator, reduces hematoma-induced brain edema, neuronal death, brain atrophy and neurological deficits. Iron chelation with deferoxamine could be a new therapy for ICH.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, University of Michigan, 5018 BSRB, 109 Zina Pitcher Pl, Ann Arbor, MI, 48109-2200, USA

    Ya Hua MD, Richard F. Keep PhD, Yuxiang Gu MD, PhD & Guohua Xi MD

Authors
  1. Ya Hua MD
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  2. Richard F. Keep PhD
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  3. Yuxiang Gu MD, PhD
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  4. Guohua Xi MD
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Corresponding author

Correspondence to Guohua Xi MD .

Editor information

Editors and Affiliations

  1. , Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, 90048, California, USA

    Paul A. Lapchak

  2. Loma Linda University, 11234 Anderson Street, Room 2562B, Loma Linda, 92354, California, USA

    John H. Zhang

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Hua, Y., Keep, R.F., Gu, Y., Xi, G. (2012). Iron as a Therapeutic Target in Intracerebral Hemorrhage: Preclinical Testing of Deferoxamine. In: Lapchak, P., Zhang, J. (eds) Translational Stroke Research. Springer Series in Translational Stroke Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9530-8_21

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