Iron as a Therapeutic Target in Intracerebral Hemorrhage: Preclinical Testing of Deferoxamine

  • Ya Hua
  • Richard F. Keep
  • Yuxiang Gu
  • Guohua Xi
Part of the Springer Series in Translational Stroke Research book series (SSTSR)


Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality. Experimental studies have found that brain iron overload occurs after ICH and iron has a key role in ICH-induced brain injuiry. Deferoxamine, an iron chelator, reduces hematoma-induced brain edema, neuronal death, brain atrophy and neurological deficits. Iron chelation with deferoxamine could be a new therapy for ICH.


Iron Overload Brain Edema Iron Chelator Brain Atrophy Edema Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Ya Hua
    • 1
  • Richard F. Keep
    • 1
  • Yuxiang Gu
    • 1
  • Guohua Xi
    • 1
  1. 1.Department of NeurosurgeryUniversity of MichiganAnn ArborUSA

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