Angiogenesis and Arteriogenesis as Stroke Targets

Chapter
Part of the Springer Series in Translational Stroke Research book series (SSTSR)

Abstract

Stroke is the third leading cause of morbidity and long-term disability. Reestablishment of functional microvasculature such as promotion of angiogenesis and arteriogenesis in the ischemic border creates a hospitable microenvironment for neuronal plasticity leading to functional recovery. To capitalize on angiogenesis and arteriogenesis as therapeutic targets for stroke treatment, knowledge of the precise molecular mechanisms which stimulate these vascular processes is necessary. Vascular endothelial growth factor, its receptors, the Angiopoietin-1 (Ang1)/Tie2 system and endothelial nitric oxide synthase, among other angiogenic factors mediate and contribute to post-ischemic angiogenesis and arteriogenesis. This chapter reviews molecular mechanisms which promote angiogenesis and arteriogenesis following cerebral ischemia and the associated vascular remodeling effects of experimental pharmacological (Statins and Niaspan) and cellular (bone marrow stromal cells) approaches for the treatment of stroke.

Keywords

Placebo Cholesterol Permeability Migration Ischemia 

Notes

Acknowledgments

This work was supported by National Institute of Aging grant RO1 AG301811 (J.C) and R01-AG037506 (M.C).

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of NeurologyHenry Ford HospitalDetroitUSA
  2. 2.Department of NeurologyHenry Ford HospitalDetroitUSA
  3. 3.Department of PhysicsOakland UniversityRochesterUSA

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