Summary and Conclusion

  • Francesco Chiappelli


We have attempted to present a framework for translational evidence-based osteoimmunology and osteoimmunopathology. We have established the biological foundations of the emerging understanding of the interactions between the bone system and the immune system. We reviewed the cellular, molecular, and proteomic pathways that converge to bone metabolism on one hand, and cell-mediated immunity on the other. More importantly, we described and discussed the multiple cross-regulatory mechanisms through which osteology and immunology sustain each other, and on each other.

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.School of Dentistry Division of Oral Biology & MedicineUniversity of California at Los AngelesLos AngelesUSA
  2. 2.American Association of Oral Biologists Evidence-Based Dentistry ChampionAmerican Dental AssociationLos AngelesUSA

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