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Immunology of Head and Neck Cancer

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Head and Neck Cancer

Abstract

The immune system plays a key role in the ­progression of head and neck cancer. A greater understanding of the important contribution of the dysregulation and evasion of the immune system in the development and evolution of head and neck cancers should lead to improved therapies and outcomes for patients. Head and neck cancer evades the host immune system through manipulation of its own immunogenicity, production of immunosuppressive molecules, and promotion of immunomodulatory cell types. Also, the immune system can be exploited to promote metastasis, angiogenesis, and growth. In this chapter, we review basic immunology as it relates to head and neck cancer and discuss the theory of cancer immunosurveillance and immune escape. Current research on cytokines as biomarkers, cancer stem cell tumor antigens, and immunotherapeutic strategies are presented.

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  1. University of Pittsburgh Cancer Institute, 200 Lothrop Street, Suite 500, Pittsburgh, PA, 15213, USA

    Robert L. Ferris

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Correspondence to Robert L. Ferris .

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  1. , Dept of Radio-Oncology, Genolier Swiss Medical Network, 4 Route du Muids, Genolier, CH-1272, Switzerland

    Jacques Bernier

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Lee, S.C., Ferris, R.L. (2011). Immunology of Head and Neck Cancer. In: Bernier, J. (eds) Head and Neck Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9464-6_6

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  • DOI: https://doi.org/10.1007/978-1-4419-9464-6_6

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