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Multidisciplinary Management of Skull Base and Superstructure Tumors

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Head and Neck Cancer

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Abstract

Malignant tumors of the paranasal sinuses are rare, accounting for only 3% of all the head and neck malignancies. As a consequence, no report of a randomized clinical trial about different treatments has been published, and the chance to perform such a trial is remote. However, the combination of surgery and (chemo)-radiotherapy seems to offer better local control than radiotherapy alone.The treatment of skull base tumors is, by definition, a multidisciplinary work. Even in cases were surgery may be the only treatment, at least a neurosurgeon and a head and neck surgeon must collaborate to reach good results avoiding complications. Plastic and reconstructive surgeons, radiologists, anesthesiologists, critical care and rehabilitations experts, and nurses are also indispensable. Moreover, the quite steady indication for pre- or postoperative (chemo)-radiotherapy involves the involvement of medical oncologists and radiotherapists in the therapeutic team.This chapter will demonstrate in details the above-­mentioned principles, mentioning the more recent papers on this topic and my own large experience in the treatment of malignant skull base tumors. Moreover, I will take into ­consideration the most frequent histologic types and their different etiology and standard or experimental treatment.

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References

  1. Muir CS, Nectoux J. Descriptive epidemiology of malignant neoplasms of nose, nasal cavities, middle ear and accessory sinuses. Clin Otolaryngol Allied Sci. 1980;5:195–211.

    Article  PubMed  CAS  Google Scholar 

  2. Newman DA. A case of adeno-carcinoma of the left inferior turbinate boby, and perforation of the nasal septum, in the person of a worker in chrome pigments. Glasgow Med J. 1890;33:469–70.

    Google Scholar 

  3. ‘t Mannetje A, Kogevinas M, Luce D, et al. Sinonasal cancer, occupation, and tobacco smoking in European women and men. Am J Ind Med. 1999;36(1):101–7.

    PubMed  Google Scholar 

  4. Acheson ED, Cowdell RH, Hadfield E, Macbeth RG. Nasal cancer in woodworkers in the furniture industry. Br Med J. 1968;2:587–96.

    Article  PubMed  CAS  Google Scholar 

  5. Hadfield EH. A study of adenocarcinoma of the paranasal sinuses in woodworkers in the furniture industry. Ann R Coll Surg Engl. 1970;46(6):301–19.

    PubMed  CAS  Google Scholar 

  6. Klintenberg C, Olofsson J, Hellquist H, et al. Adenocarcinoma of the ethmoid sinuses. A review of 28 cases with special reference to wood dust exposure. Cancer. 1984;54(3):482–8.

    Article  PubMed  CAS  Google Scholar 

  7. Luce D, Leclerc A, Morcet JF, et al. Occupational risk factors for sinonasal cancer: a case-control study in France. Am J Ind Med. 1992;21(2):163–75.

    Article  PubMed  CAS  Google Scholar 

  8. Acheson ED. Nasal cancer in the furniture and boot and shoe manufacturing industries. Prev Med. 1976;5(2):295–315.

    Article  PubMed  CAS  Google Scholar 

  9. Hernberg S, Westerholm P, Shultz-Larsen K, et al. Nasal and sinonasal cancer. Connection with occupational exposures in Denmark, Finland and Sweden. Scand J Work Environ Health. 1983;9(4):315–26.

    PubMed  CAS  Google Scholar 

  10. Hadfield EH, Macbeth RG. Adenocarcinoma of the ethmoids in furniture workers. Ann Otol Rhinol Laryngol. 1971;80(5):699–703.

    PubMed  CAS  Google Scholar 

  11. Bimbi G, Saraceno MS, Riccio S, et al. Adenocarcinoma of the ethmoid sinus: an occupational disease. Acta Otorhinolaryngol Ital. 2004;24(4):199–203.

    PubMed  CAS  Google Scholar 

  12. Voss R, Stenersen T, Roald Hoppedal B, et al. Sinonasal cancer and exposure to softwood. Acta Otolaryngol. 1985;99(1–2):172–88.

    Article  PubMed  CAS  Google Scholar 

  13. Carton M, Goldberg M, Luce D. Occupational exposure to wood dust. Health effects and exposure limit values. Rev Epidemiol Sante Publique. 2002;50(2):159–78.

    PubMed  CAS  Google Scholar 

  14. Roux FX, Pages JC, Nataf F, et al. Malignant ethmoid-sphenoidal tumors. 130 cases. Retrospective study. Neurochirurgie. 1997;43(2):100–10.

    PubMed  CAS  Google Scholar 

  15. Suarez C, Suarez C, Llorente JL, Fernandez De Leon R, et al. Prognostic factors in sinonasal tumors involving the anterior skull base. Head Neck. 2004;26(2):136–44.

    Article  PubMed  Google Scholar 

  16. Cantu G, Solero CL, Miceli R, et al. Which classification for ethmoid malignant tumors involving the anterior skull base? Head Neck. 2005;27(3):224–31.

    Article  PubMed  Google Scholar 

  17. Cheesman AD. Craniofacial resection for tumors of the nasal cavity and paranasal sinuses. Head Neck Surg. 1986;8(6):429–35.

    Article  PubMed  CAS  Google Scholar 

  18. McCutcheon IE, Blacklock JB, Weber RS, et al. Anterior transcranial (craniofacial) resection of tumors of the paranasal sinuses: surgical technique and results. Neurosurgery. 1996;38(3):471–9. discussion 479–80.

    PubMed  CAS  Google Scholar 

  19. Bentz BG, Bilsky MH, Shah JP, et al. Anterior skull base surgery for malignant tumors: a multivariate analysis of 27 years of experience. Head Neck. 2003;25(7):515–20.

    Article  PubMed  Google Scholar 

  20. Donald PJ. Complications in skull base surgery for malignancy. Laryngoscope. 1999;109(12):1959–66.

    Article  PubMed  CAS  Google Scholar 

  21. Irish JC, Gullane PJ, Gentili F, et al. Tumors of the skull base: outcome and survival analysis of 77 cases. Head Neck. 1994;16(1):3–10.

    Article  PubMed  CAS  Google Scholar 

  22. Bridger GP, Kvok B, Baldwin M, et al. Craniofacial resection for paranasal sinus cancers. Head Neck. 2000;22(8):772–80.

    Article  PubMed  CAS  Google Scholar 

  23. Blot WJ, Chow WH, McLaughlin JK. Wood dust and nasal cancer risk. A review of the evidence from North America. J Occup Environ Med. 1997;39(2):148–56.

    Article  PubMed  CAS  Google Scholar 

  24. Nylander LA, Dement JD. Carcinogenetics effects of wood dust: review and discussion. Am J Ind Med. 1993;24(5):619–47.

    Article  PubMed  CAS  Google Scholar 

  25. Pastore E, Perrone F, Orsenigo M, et al. Polymorphisms of metabolizing enzymes and susceptibility to ethmoid intestinal-type adenocarcinoma in professionally exposed patients. Transl Oncol. 2009;2(2):84–8.

    PubMed  Google Scholar 

  26. Barnes L, Everson JW, Reichart P, et al. World Health Organization classification of tumours: pathology & genetics-head and neck tumours. Lyon, France: IARC Press; 2005.

    Google Scholar 

  27. Dulguerov P, Jacobsen MS, Allal AS, et al. Nasal and paranasal sinus carcinoma: are we making progress? Cancer. 2001;92(12):3012–29.

    Article  PubMed  CAS  Google Scholar 

  28. Katz TS, Mendenhall WM, Morris CG, et al. Malignant tumors of the nasal cavity and paranasal sinuses. Head Neck. 2002;24(9):821–9.

    Article  PubMed  Google Scholar 

  29. Schantz SP, Harrison LB, Forastiere AA. Tumors of the nasal cavity and paranasal sinuses. In: De Vita Jr VT, Hellman S, Rosemberg SA, editors. Cancer. Principles & practice of oncology. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 819–24.

    Google Scholar 

  30. Le QT, Fu KK, Kaplan MJ, Terris DJ, et al. Lymph none metastasis in maxillary sinus carcinoma. Int J Radiat Oncol Biol Phys. 2000;46(3):541–9.

    Article  PubMed  CAS  Google Scholar 

  31. Paulino AC, Fisher SG, Marks JE. Is prophylactic neck irradiation indicated in patients with squamous cell carcinoma of the maxillary sinus? Int J Radiat Oncol Biol Phys. 1997;39(2):283–9.

    PubMed  CAS  Google Scholar 

  32. Kim GE, Chung EJ, Lim JJ, et al. Clinical significance of neck node metastasis in squamous cell carcinoma of the maxillary antrum. Am J Otolaryngol. 1999;20(6):383–90.

    Article  PubMed  CAS  Google Scholar 

  33. Bhattacharyya N. Factor affecting survival in maxillary sinus cancer. J Oral Maxillofac Surg. 2003;61(9):10016–1021.

    Article  Google Scholar 

  34. Cantù G, Bimbi G, Miceli R, et al. Lymph node metastases in paranasal sinuses malignant tumors: prognostic value and treatment. Arch Otolaryngol Head Neck Surg. 2008;134(2):170–7.

    Article  PubMed  Google Scholar 

  35. del Regato JA. Roentgentherapy in epitheliomas of the maxillary sinus. Surg Gynecol Obstet. 1937;65:657–65.

    Google Scholar 

  36. Sisson GA, Johnson NE, Amiri CS. Cancer of the maxillary sinus. Clinical classification and management. Ann Otol Rhinol Laryngol. 1963;72(12):1050–9.

    PubMed  CAS  Google Scholar 

  37. Sakai S, Hamasaki Y. Proposal for the classification of carcinoma of the paranasal sinuses. Acta Otolaryngol (Stockolm). 1967;63(1):42–8.

    Article  CAS  Google Scholar 

  38. Lederman M. Cancer of the upper jaw and nasal chambers. Proc R Soc Med. 1969;62(1):65–72.

    PubMed  CAS  Google Scholar 

  39. Rubin P. Cancer of the head and neck: nose, paranasal sinuses. JAMA. 1972;219(3):336–8.

    Article  PubMed  CAS  Google Scholar 

  40. Chandler JR, Guillamondegui OM, Sisson GA, et al. Clinical staging of cancer of the head and neck: a new “new” system. Am J Surg. 1976;132(4):525–8.

    Article  PubMed  CAS  Google Scholar 

  41. Harrison DF. Critical look at the classification of maxillary sinus carcinomata. Ann Otol Rhinol Laryngol. 1978;87(1pt1):3–9.

    PubMed  CAS  Google Scholar 

  42. Sebileau P. Les formes cliniques du cancer du sinus maxillaire. Annales malades d’oreille, du larynx, nez et pharynx. 1906;32:430–50.

    Google Scholar 

  43. Öhngren LG. Malignant tumors of the maxillary-ethmoidal region. Acta Otolaryngol (Stockolm). 1933;19:1–476.

    Google Scholar 

  44. AJCC. Manual for staging of cancer 1977. Chicago, IL: American Joint Committee; 1977. p. 45–8.

    Google Scholar 

  45. Beahrs OH, Myers MH. AJCC manual for staging of cancer. 2nd ed. Philadelphia, PA: J.B. Lippincott Company; 1983. p. 43–8.

    Google Scholar 

  46. Beahrs OH, Henson DE, Hutter RVP, et al. AJCC manual for staging of cancer. 3rd ed. Philadelphia, PA: J.B. Lippincott Company; 1988. p. 45–50.

    Google Scholar 

  47. Beahrs OH, Henson DE, Hutter RVP, et al. AJCC manual for staging of cancer. 4th ed. Philadelphia, PA: J.B. Lippincott Company; 1992. p. 45–8.

    Google Scholar 

  48. Hermanek P, Sobin LH. UICC TNM classification of malignant tumours. Berlin: Springer; 1987. p. 27–9.

    Google Scholar 

  49. Sisson GA, Toriumi DM, Atiyah RA. Paranasal sinus malignancy: a comprehensive update. Laryngoscope. 1989;99(2):143–50.

    Article  PubMed  Google Scholar 

  50. Spiro JD, Soo KC, Spiro RH. Nonsquamous cell malignant neoplasms of the nasal cavities and paranasal sinuses. Head Neck. 1995;17(2):114–8.

    Article  PubMed  CAS  Google Scholar 

  51. Kadish S, Goodman M, Wang CC. Olfactory neuroblastoma. A clinical analysis of 17 cases. Cancer. 1976;37(3):1571–6.

    Article  PubMed  CAS  Google Scholar 

  52. Biller HF, Lawson W, Sachdev VP, et al. Esthesioneuroblastoma: surgical treatment without radiation. Laryngoscope. 1990;100(11):1199–201.

    Article  PubMed  CAS  Google Scholar 

  53. Dulguerov P, Calcaterra T. Esthesioneuroblastoma: the UCLA experience 1970–1990. Laryngoscope. 1992;102(8):843–9.

    Article  PubMed  CAS  Google Scholar 

  54. Ellingwood KE, Million RR. Cancer of the nasal cavity and ethmoid/sphenoid sinuses. Cancer. 1979;43(4):1517–26.

    Article  PubMed  CAS  Google Scholar 

  55. Roux FX, Brasnu D, Menard M, et al. Combined approach to malignant tumors of the ethmoid and other paranasal sinuses. Principles and results. Ann Otolaryngol Chir Cervicofac. 1991;108(5):292–7.

    PubMed  CAS  Google Scholar 

  56. Cantu G, Solero CL, Salvatori P, et al. A new classification of malignant ethmoid tumors. 3rd European Skull Base Congress. London, 9–11 April 1997. Skull Base Surg. 1997;7 Suppl 2:33.

    Google Scholar 

  57. American Joint Committee on Cancer. AJCC cancer staging manual. 5th ed. Philadelphia, PA: Lippincot-Raven; 1997.

    Google Scholar 

  58. Sobin LH, Wettekind C, editors. TNM classification of malignant tumours. 5th ed. New York, NY: John Wiley & Sons Inc; 1997.

    Google Scholar 

  59. American Joint Committee on Cancer. AJCC cancer staging manual. 6th ed. New York, NY: Springer-Verlag; 2002.

    Google Scholar 

  60. UICC. TNM classification of malignant tumours. 6th ed. New York, NY: Wiley-Liss; 2002.

    Google Scholar 

  61. Cantù G, Solero CL, Miceli R, et al. Which classification for ethmoid malignant tumors involving the anterior skull base? Head Neck. 2005;27(3):224–31.

    Article  PubMed  Google Scholar 

  62. Dulguerov P, Allal AS. Nasal and paranasal sinus carcinoma: how can we continue to make progress? Curr Opin Otolaryngol Head Neck Surg. 2006;14(2):67–72.

    PubMed  Google Scholar 

  63. Cohen ZR, Marmor WE, Fuller GN, et al. Misdiagnosis of olfactory neuroblastoma. Neurosurg FocusNeurosurg Focus. 2002;12(5):e3.

    Google Scholar 

  64. Ganly I, Patel SG, Singh B, et al. Craniofacial resection for malignant paranasal sinus tumors: report of an International Collaborative Study. Head Neck. 2005;27(7):575–84.

    Article  PubMed  Google Scholar 

  65. Cantù G, Solero CL, Mariani L, et al. Anterior craniofacial resection for malignant ethmoid tumors – a series of 91 patients. Head Neck. 1999;21(3):185–91.

    Article  PubMed  Google Scholar 

  66. Patel SG, Singh B, Polluri A, et al. Craniofacial surgery for malignant skull base tumors: report of an international collaborative study. Cancer. 2003;98(6):1179–87.

    Article  PubMed  Google Scholar 

  67. Waldron J, Witterick I. Paranasal sinus cancer: caveats and controversies. World J Surg. 2003;27(7):849–55.

    Article  PubMed  Google Scholar 

  68. Waldron JN, O’Sullivan B, Warde P, et al. Ethmoid sinus cancer: twenty-nine cases managed with primary radiation therapy. Int J Radiat Oncol Biol Phys. 1998;41(2):361–9.

    Article  PubMed  CAS  Google Scholar 

  69. Stell PM. History of surgery of the upper jaw. In: Harrison D, Lund VJ, editors. Tumours of the upper jaw. Edinburgh: Ed Churchill Livingstone; 1993. p. 1–15.

    Google Scholar 

  70. Conley JJ. The surgical approach to the pterygoid area. Ann Surg. 1956;144(1):39–43.

    Article  PubMed  CAS  Google Scholar 

  71. Crockett DJ. Surgical approach to the back of the maxilla. Br J Surg. 1963;50:819–21.

    Article  PubMed  CAS  Google Scholar 

  72. Dingman DL, Conley JJ. Lateral approach to the pterygomaxillary region. Ann Otol Rhinol Laryngol. 1970;79(5):967–9.

    PubMed  CAS  Google Scholar 

  73. Smith RR, Klopp CT, Williams JM. Surgical treatment of cancer of the frontal sinus and adjacent areas. Cancer. 1954;7(5):991–4.

    Article  PubMed  CAS  Google Scholar 

  74. Malecki J. New trends in frontal sinus surgery. Acta Otolaryngol. 1959;50(2):137–40.

    Article  PubMed  CAS  Google Scholar 

  75. Ketcham AS, Wilkins RH, Van Buren JM, et al. A combined intracranial facial approach to the paranasal sinuses. Am J Surg. 1963;106:698–703.

    Article  PubMed  CAS  Google Scholar 

  76. Patel SG, Singh B, Polluri A, et al. Craniofacial surgery for malignant skull base tumors. Report of an International Collaborative Study. Cancer. 2003;98(6):1179–87.

    Article  PubMed  Google Scholar 

  77. Ganly I, Patel SG, Singh B, et al. Craniofacial resection for malignant paranasal sinus tumors: report of an International Collaborative Study. Head Neck. 2005;27(7):575–84.

    Article  PubMed  Google Scholar 

  78. Ketcham AS, Van Buren JM. Tumors of the paranasal sinuses: a therapeutic challenge. Am J Surg. 1985;150(4):406–13.

    Article  PubMed  CAS  Google Scholar 

  79. Stern SJ, Goepfert H, Clayman G, et al. Orbital preservation in maxillectomy. Otolaryngol Head Neck Surg. 1993;109(1):111–5.

    PubMed  CAS  Google Scholar 

  80. Cantu G, Solero CL, Riccio S, et al. Surgery for malignant maxillary tumors involving the middle cranial fossa. Skull Base. 2010;20(2):55–60.

    Google Scholar 

  81. Nicolai P, Castelnuovo P, Lombardi D, et al. Role of endoscopic surgery in the management of selected malignant epithelial neoplasms of the naso-ethmoidal complex. Head Neck. 2007;29(12):1075–82.

    Article  PubMed  Google Scholar 

  82. Nicolai P, Battaglia P, Bignami M, et al. Endoscopic surgery for malignant tumors of the sinonasal tract and adjacent skull base: a 10-year experience. Am J Rhinol. 2008;22(3):308–16.

    Article  PubMed  Google Scholar 

  83. Choi HR, Sturgis EM, Rashid A, et al. Sinonasal adenocarcinoma: evidence for histogenetic divergence of the enteric and nonenteric phenotypes. Hum Pathol. 2003;34(11):1101–7.

    Article  PubMed  Google Scholar 

  84. Kennedy MT, Jordan RCK, Berean KW, et al. Expression pattern of CK7, CK20, CDX-2, and villin in intestinal-type sinonasal adenocarcinoma. J Clin Pathol. 2004;57(9):932–7.

    Article  PubMed  CAS  Google Scholar 

  85. Batsakis JG. Mucous gland tumors of the nose and paranasal sinuses. Ann Otol Rhinol Laryngol. 1970;79(3):557–62.

    PubMed  CAS  Google Scholar 

  86. Katz TS, Mendenhall WM, Morris CG, et al. Malignant tumors of the nasal cavity and paranasal sinuses. Head Neck. 2002;24(9):821–9.

    Article  PubMed  Google Scholar 

  87. Tanzler ED, Morris CG, Orlando CA, et al. Management of sinonasal undifferentiated carcinoma. Head Neck. 2008;30(5):595–9.

    Article  PubMed  Google Scholar 

  88. Guntinas-Lichius O, Kreppel MP, Stuetzer H, et al. Single modality and multimodality treatment of nasal and paranasal sinuses cancer: a single institution experience of 229 patients. Eur J Surg Oncol. 2007;33(2):222–8.

    PubMed  CAS  Google Scholar 

  89. Hoppe BS, Stegman LD, Zelefsky MJ, et al. Treatment of nasal cavity and paranasal sinus cancer with modern radiotherapy techniques in the postoperative setting – the MSKCC experience. Int J Radiat Oncol Biol Phys. 2007;67(3):691–702.

    Article  PubMed  Google Scholar 

  90. Douglas JC, Laramore GE, Austin-Seymour M, et al. Neutron radiotherapy for adenoid cystic carcinoma of the minor salivary gland. Int J Radiat Oncol Biol Phys. 1996;36:87–93.

    Article  PubMed  CAS  Google Scholar 

  91. Douglas JG, Laramore GE, Austin-Seymour M, et al. Treatment of locally advanced adenoid cystic carcinoma of the head and neck with neutron radiotherapy. Int J Radiat Oncol Biol Phys. 2000;46(3):551–7.

    Article  PubMed  CAS  Google Scholar 

  92. Pommier P, Liebsch NJ, Deschler DG, et al. Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg. 2006;132(11):1242–9.

    Article  PubMed  Google Scholar 

  93. Brada M, Pijls-Johannesma M, De Ruysscher D. Proton therapy in clinical practice: current clinical evidence. J Clin Oncol. 2007;25(8):965–70.

    Article  PubMed  Google Scholar 

  94. Sato Y, Morita M, Takahashi HO, et al. Combined surgery, radiotherapy, and regional chemotherapy in carcinoma of the paranasal sinuses. Cancer. 1970;25(3):571–9.

    Article  PubMed  CAS  Google Scholar 

  95. Sakai S, Hohki A, Fuchihata H, et al. Multidisciplinary treatment of maxillary sinus carcinoma. Cancer. 1983;52(8):1360–4.

    Article  PubMed  CAS  Google Scholar 

  96. Kondo M, Ogawa K, Inuyama Y, et al. Prognostic factors influencing relapse of squamous cell carcinoma of the maxillary sinus. Cancer. 1985;55(1):190–6.

    Article  PubMed  CAS  Google Scholar 

  97. Tsujii H, Kamada T, Arimoto T, et al. The role of radiotherapy in the management of maxillary sinus carcinoma. Cancer. 1986;57(12):2261–6.

    Article  PubMed  CAS  Google Scholar 

  98. Shibuya H, Suzuki S, Horiuchi J, et al. Reappraisal of trimodal combination therapy for maxillary sinus carcinoma. Cancer. 1982;50(12):2790–4.

    Article  PubMed  CAS  Google Scholar 

  99. Konno A, Ishikawa K, Terada N, et al. Analysis of long-term results of our combination therapy for squamous cell cancer of the maxillary sinus. Acta Otolaryngol Suppl. 1998;537:57–66.

    PubMed  CAS  Google Scholar 

  100. Samant S, Robbins KT, Vang M, et al. Intra-arterial cisplatin and concomitant radiation therapy followed by surgery for advanced paranasal sinus cancer. Arch Otolaryngol Head Neck Surg. 2004;130(8):948–55.

    Article  PubMed  Google Scholar 

  101. Knegt PP, de Jong PC, van Andel JG, et al. Carcinoma of the paranasal sinuses. Results of a prospective pilot study. Cancer. 1985;56(1):57–62.

    Article  PubMed  CAS  Google Scholar 

  102. Knegt PP, Ah-See KW, vd Velden LA LA, et al. Adenocarcinoma of the ethmoidal sinus complex: surgical debulking and topical fluorouracil may be the optimal treatment. Arch Otolaryngol Head Neck Surg. 2001;127(2):141–6.

    PubMed  CAS  Google Scholar 

  103. Almeyda R, Capper J. Is surgical debridement and topical 5 fluorouracil the optimum treatment for woodworkers’ adenocarcinoma of the ethmoid sinuses? A case-controlled study of a 20-year experience. Clin Otolaryngol. 2008;33(5):435–41.

    Article  PubMed  CAS  Google Scholar 

  104. Licitra L, Locati LD, Bossi P, et al. Head and neck tumors other than squamous cell carcinoma. Curr Opin Oncol. 2004;16(3):236–41.

    Article  PubMed  Google Scholar 

  105. Rosen A, Vokes EE, Scher N, et al. Locoregionally advanced paranasal sinus carcinoma. Favorable survival with multimodality therapy. Arch Otolaryngol Head Neck Surg. 1993;119(7):743–6.

    PubMed  CAS  Google Scholar 

  106. Björk-Eriksson T, Mercke C, Petruson B, et al. Potential impact on tumor control and organ preservation with cisplatin and 5-­fluorouracil for patients with advanced tumors of the paranasal sinuses and nasal fossa. A prospective pilot study. Cancer. 1992;70(11):2615–20.

    Article  PubMed  Google Scholar 

  107. Licitra L, Locati LD, Cavina R, et al. Primary chemotherapy followed by anterior craniofacial resection and radiotherapy for paranasal cancer. Ann Oncol. 2003;14(3):367–72.

    Article  PubMed  CAS  Google Scholar 

  108. Licitra L, Suardi S, Bossi P, et al. Prediction of TP53 status for primary cisplatin, fluorouracil, and leucovorin chemotherapy in ethmoid sinus intestinal-type adenocarcinoma. J Clin Oncol. 2004;22(24):4901–6.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Cranio-Maxillo-Facial Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, National Cancer Institute, Via Venezian 1, Milano, 20133, Italy

    Giulio Cantù

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    Jacques Bernier

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Cantù, G., Solero, C.L., Riccio, S., Colombo, S., Pompilio, M. (2011). Multidisciplinary Management of Skull Base and Superstructure Tumors. In: Bernier, J. (eds) Head and Neck Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9464-6_26

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