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Ion Signaling and Electrophysiological Function

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Signaling in the Heart

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Abstract

The normal sequence and synchronous contraction of the heart is governed by the cardiac action potential generated by the highly regulated activity of the ion channels. Ion channels represent multiprotein complexes composed of homologous subunits circularly arranged around a water-filled pore through the plane of the membrane lipid bilayer. Based on their gating (the mechanism of opening and closing of a channel) properties, the ion channels can be divided into subclasses: the voltage-gated, ligand-gated, and mechanosensitive ion channels. In this chapter, the action potential properties and the function of major ion channels are presented.

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  1. The Molecular Cardiology and Neuromuscular Institute, Raritan Avenue 75, 08904, Highland Park, NJ, USA

    José Marín-García M.D. (Director)

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  1. José Marín-García M.D.
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Correspondence to José Marín-García M.D. .

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Marín-García, J. (2011). Ion Signaling and Electrophysiological Function. In: Signaling in the Heart. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9461-5_6

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  • DOI: https://doi.org/10.1007/978-1-4419-9461-5_6

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  • Print ISBN: 978-1-4419-9460-8

  • Online ISBN: 978-1-4419-9461-5

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