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The Physical Processes of Digestion pp 1–7Cite as

Introduction

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Abstract

The scope of the book and the broad dynamics of the digestion of food particles are outlined along with the rate-limiting potentials of the component processes. The role of locally generated motor responses in securing optimal mixing and onflow of gut content is discussed along with the concept of optimality in digestion.

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References

  • Amidon GL, Lennernäs H, Shah VP, Crison JR (1995) A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 12:413-420

    Article  CAS  Google Scholar 

  • Bornstein JC, Furness JB, Kunze WAA, Bertrand PP (2002) Enteric reflexes that influence motility. In: Brookes SJH, Costa M (eds) Innervation of the gastrointestinal tract. Taylor & Francis, London

    Google Scholar 

  • Chen L, Remondetto G, Subirade M (2006) Food protein-based materials as nutraceutical delivery systems. Trends Food Sci Technol 17:272-283

    Article  CAS  Google Scholar 

  • Cochran PA (1987) Optimal digestion in a batch-reactor gut: The analogy to partial prey consumption. Oikos 50:268-270

    Article  Google Scholar 

  • Cone RA (1999) Mucus. In: Ogra PL, Mestecky J, Lamm ME, Strober W, Bienenstock J, McGhee JR (eds) Mucosal immunology. Academic Press, San Diego, pp 43-64

    Google Scholar 

  • Cone RA (2009) Barrier properties of mucus. Adv Drug Deliv Rev 61:75-85

    Article  CAS  Google Scholar 

  • Dikeman CL, Fahey GC (2006) Viscosity as related to dietary fiber: A review. Crit Rev Food Sci Nutr 46:649-663

    Article  CAS  Google Scholar 

  • Fagerholm U, Lennernäs H (1995) Experimental estimation of the effective unstirred water layer thickness in the human jejunum, and its importance in oral drug absorption. Eur J Pharm Sci 3:247-253

    Article  CAS  Google Scholar 

  • Goodacre BC, Murray PJ (1981) A mathematical model of drug absorption. J Clin Pharm Ther 6:117-133

    Article  CAS  Google Scholar 

  • Hume ID, Sakaguchi E (1991) Patterns of digesta flow and digestion in foregut and hindgut fermenters. In: Tsuda T, Saaski Y, Kawashima R (eds) Physiological aspects of digestion and metabolism in ruminants. San Diego, Academic Press, pp 427-451

    Chapter  Google Scholar 

  • Illius AW, Gordon I (2009) Prediction of intake and digestion in ruminants by a model of rumen kinetics integrating animal size and plant characteristics. J Agric Sci 116:145-157

    Article  Google Scholar 

  • Kong F, Singh RP (2009) Digestion of raw and roasted almonds in simulated gastric environment. Food Biophysics 4:365-377

    Article  Google Scholar 

  • Lehmann U, Robin F (2007) Slowly digestible starch–its structure and health implications: A review. Trends Food Sci Technol 18:346-355

    Article  CAS  Google Scholar 

  • Lentle RG, Hemar Y, Hall CE, Stafford KJ (2005) Periodic fluid extrusion and models of digesta mixing in the intestine of a herbivore, the common brushtail possum (trichosurus vulpecula). J Comp Physiol B175:337-347

    Google Scholar 

  • Lentle RG, Janssen PWM, Asvarujanon P, Chambers P, Stafford KJ, Hemar Y (2007) High definition mapping of circular and longitudinal motility in the terminal ileum of the brushtail possum trichosurus vulpecula with watery and viscous perfusates. J Comp Physiol B177:543-556

    Google Scholar 

  • Lentle RG, Janssen PWM, Goh K, Chambers P, Hulls C (2010) Quantification of the effects of the volume and viscosity of gastric contents on antral and fundic activity in the rat stomach maintained ex vivo. Dig Dis Sci DOI 10.1007/s10620-010-1164-y:1-12

    Google Scholar 

  • Levitt MD, Furne JK, Strocchi A, Anderson BW, Levitt DG (1990) Physiological measurements of luminal stirring in the dog and human small bowel. J Clin Invest 86:1540-1547

    Article  CAS  Google Scholar 

  • Lucas P (2004) Dental functional morphology. Cambridge University Press, Cambridge

    Book  Google Scholar 

  • Macagno EO, Christensen JM (1980) Fluid mechanics of the duodenum. Annu Rev Fluid Mech 12:139-158

    Article  Google Scholar 

  • Macagno EO, Christensen JM (1981) Fluid mechanics of gastrointestinal flow. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven, New York, pp 335-358

    Google Scholar 

  • Mandalari G, Faulks R, Rich G, Lo Turco V, Picout D, Lo Curto R, Bisignano G, Dugo P, Dugo G, Waldron K (2008) Release of protein, lipid, and vitamin E from almond seeds during digestion. J Agric Food Chem 56:3409-3416

    Article  CAS  Google Scholar 

  • Melville J, Macagno E, Christensen J (1975) Longitudinal contractions in the duodenum: Their fluid-mechanical function. Am J Physiol 228:1887-1892

    CAS  Google Scholar 

  • Oh DM, Curl RL, Amidon GL (1993) Estimating the fraction dose absorbed from suspensions of poorly soluble compounds in humans: A mathematical model. Pharm Res 10:264-270

    Article  CAS  Google Scholar 

  • Pappenheimer JR (2001) Role of pre-epithelial ‘unstirred’ layers in absorption of nutrients from the human jejunum. J Membr Biol 179:185-204

    Article  CAS  Google Scholar 

  • Penry DL, Jumars PA (1987) Modeling animal guts as chemical reactors. Am Nat 129:69-96

    Article  CAS  Google Scholar 

  • Reigner BG, Couet W, Guedes J-P, Fourtilla JB, Tozer TN (1990) Saturable rate of cefatrizine absorption after oral administration to humans. J Pharmacokinet Biopharm 18:17-34

    Article  CAS  Google Scholar 

  • Reuterswärd AL, Fabiansson S (1985) In vivo digestibility of insoluble collagen from bovine tendon as influenced by the inhibition of gastric acid secretion. J Food Sci 50:1523-1525

    Article  Google Scholar 

  • Schoener TW (1971) Theory of feeding strategies. Annu Rev Ecol Syst 2:369-404

    Article  Google Scholar 

  • Shameem M, Katori N, Aoyagi N, Kojima S (1995) Oral solid controlled release dosage forms: Role of GI-mechanical destructive forces and colonic release in drug absorption under fasted and fed conditions in humans. Pharm Res 12:1049-1054

    Article  CAS  Google Scholar 

  • Sibly RM (1981) Strategies of digestion and defecation. In: Townsend CR, Calow P (eds) Physiological ecology: An evolutionary approach to resource use. Blackwell, Oxford, pp 109-139

    Google Scholar 

  • Sibly RM, Calow P (1986) Physiological ecology of animals: An evolutionary approach. Blackwell, Oxford

    Google Scholar 

  • Smith TK, Furness JB (1988) Reflex changes in circular muscle activity elicited by stroking the mucosa: An electrophysiological analysis in the isolated guinea-pig ileum. J Auton Nerv Syst 25:205-218

    Article  CAS  Google Scholar 

  • Smith TK, Oliver GR, Hennig GW, O’Shea DM, Berghe PV, Kang SH, Spencer NJ (2003) A smooth muscle tone-dependent stretch-activated migrating motor pattern in isolated guinea-pig distal colon. J Physiol 551:955-969

    Article  CAS  Google Scholar 

  • Spencer NJ, Hennig GW, Smith TK (2002) A rhythmic motor pattern activated by circumferential stretch in guinea-pig distal colon. J Physiol 545:629-648

    Article  CAS  Google Scholar 

  • Spencer NJ, Hennig GW, Smith TK (2003) Stretch-activated neuronal pathways to longitudinal and circular muscle in guinea pig distal colon. Am J Physiol 284:G231-241

    CAS  Google Scholar 

  • Trendelenburg P (1917) Physiologische und pharmakologische versuche über die dünndarmperistaltik. Naunyn Schmiedebergs Arch Pharmacol 81:55-129

    Article  Google Scholar 

  • Won KJ, Sanders KM, Ward SM (2005) Interstitial cells of Cajal mediate mechanosensitive responses in the stomach. Proc Natl Acad Sci USA 102:14913-14918

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Food Nutrition and Human Health, Massey University, 11-222, Palmerston North, New Zealand

    Roger G. Lentle & Dr. Patrick W. M. Janssen

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  1. Roger G. Lentle
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  2. Dr. Patrick W. M. Janssen
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Correspondence to Patrick W. M. Janssen .

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Lentle, R.G., Janssen, P.W. (2011). Introduction. In: The Physical Processes of Digestion. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9449-3_1

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