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TH17 Cells in Health and Disease pp 463–480Cite as

IL-23/TH17 Pathway in Psoriasis and Inflammatory Skin Diseases

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Abstract

Psoriasis is a highly prevalent and heritable skin disease that affects the population worldwide. While the importance of activated T cells in disease pathogenesis has long been appreciated, the central role of the IL-23/TH17 pathway has only recently been realized. In this chapter, we discuss the contributions of TH17 cells in psoriasis, as well as in other inflammatory skin diseases.

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Acknowledgement

This publication was made possible by grant number 5UL1RR024143 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. JGK has received research grants from Amgen, Centocor, Wyeth and Eli Lilly for the study of therapeutic agents related to the IL-23/TH17 pathway.

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  1. Laboratory for Investigative Dermatology, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA

    James G. Krueger

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  1. Kristine E. Nograles
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  2. Batya Davidovici
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  3. James G. Krueger
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Correspondence to James G. Krueger .

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  1. King's College London, Department of Nephrology and Transplanta, Guy's Hospital, London, WC2R 2LS, United Kingdom

    Shuiping Jiang

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Nograles, K.E., Davidovici, B., Krueger, J.G. (2011). IL-23/TH17 Pathway in Psoriasis and Inflammatory Skin Diseases. In: Jiang, S. (eds) TH17 Cells in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9371-7_25

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