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The Roles of IL-22 and Its Related Family Members in the Pathogenesis of Psoriasis

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TH17 Cells in Health and Disease

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Abstract

IL-22 is a TH17 cytokine. It belongs to IL-10 family of cytokines that also includes IL-10, IL-19, IL-20, IL-24, and IL-26. IL-26 is also produced by TH17 cells, while IL-24 is a TH2 cytokine. All of these cytokines can also be produced by other leukocytes. Cytokine networks play essential roles in the pathogenesis of psoriasis. In psoriatic skin, the expression of IL-19, IL-20, IL-22, IL-24 and IL-26 is elevated. Infiltrating immune cells are the primary cellular sources. However, the receptors for these cytokines are expressed mainly on epithelial cells, including keratinocytes, but not on leukocytes. In psoriatic skin, these cytokines induce epidermal keratinocytes to display many pathogenic features, including hyperplasia, abnormal differentiation, and overexpression of psoriasin and other psoriatic markers. These cytokines mediate the crosstalk between infiltrating immune cells and epidermal keratinocytes.

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Authors and Affiliations

  1. Immunology Department, Genentech, Inc., South San Francisco, CA, 94080, USA

    Wenjun Ouyang

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  1. Patricia Valdez
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  2. Wenjun Ouyang
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Correspondence to Wenjun Ouyang .

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  1. King's College London, Department of Nephrology and Transplanta, Guy's Hospital, London, WC2R 2LS, United Kingdom

    Shuiping Jiang

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Valdez, P., Ouyang, W. (2011). The Roles of IL-22 and Its Related Family Members in the Pathogenesis of Psoriasis. In: Jiang, S. (eds) TH17 Cells in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9371-7_24

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