The Roles of IL-17A and IL-17F in Mucosal Infection and Allergy

  • Harumichi Ishigame
  • Susumu Nakae
  • Yoichiro Iwakura


TH17 cells are a subset of CD4+ helper T cells that produce IL-17A, IL-17F, IL-9, IL-21, and IL-22. They play an important role in promoting allergic and auto-immune responses as well as in protecting hosts against pathogens. Because IL-17A and IL-17F have the highest homology among IL-17 family members and bind the same IL-17RA and IL-17RC receptor complex, it is suggested that these two cytokines have similar functions. However, accumulating evidence suggests that these cytokines have overlapping yet distinct roles in the immune system. In this review, we introduce how IL-17A and IL-17F are involved in inflammatory immune responses and host defense mechanisms and discuss their relationship with other cytokines in the development of inflammatory and infectious diseases.


TH17 Cell Dextran Sodium Sulfate TH17 Cell Differentiation Induce TH17 Cell Ovum Inhalation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work is supported by Grants in Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan and Core Research for Evolutional Science and Technology of the Japan.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Harumichi Ishigame
  • Susumu Nakae
  • Yoichiro Iwakura
    • 1
    • 2
  1. 1.Center for Experimental Medicine and Systems Biology, The Institute of Medical ScienceThe University of TokyoMinato-kuJapan
  2. 2.Core Research for Evolutional Science and Technology (CREST)Japan Science and Technology AgencySaitamaJapan

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