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Trafficking Receptors and Migration of TH17 Cell Subsets

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TH17 Cells in Health and Disease

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Abstract

TH17 cells produce IL17 and other cytokines that regulate anti-microbial and auto-immune responses. It is well established that TH1 and TH2 effector T cells differ from each other in migratory behavior. FoxP3+ regulatory T cells apparently have the migratory features of both naïve and effector T cells. It is a question of interest if TH17 cells would display a unique trafficking behavior specific for this T cell lineage. TH17 cells are highly enriched in the intestine and other tissues with certain types of inflammatory diseases. TH17 cells are unique in that almost all of these T cells express the chemokine receptor CCR6. Otherwise, TH17 cells are considered conventional, heterogeneously expressing a number of other memory/effector type trafficking receptors, which are required for migration of TH17 cells into various tissues. I will review our current understanding of the trafficking receptors and migration behavior of TH17 cell subsets.

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  1. Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, 725 Harrison Street, West Lafayette, IN, 47907, USA

    Chang H. Kim

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  1. Chang H. Kim
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Correspondence to Chang H. Kim .

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  1. King's College London, Department of Nephrology and Transplanta, Guy's Hospital, London, WC2R 2LS, United Kingdom

    Shuiping Jiang

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© 2011 Springer Science+Business Media, LLC

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Kim, C.H. (2011). Trafficking Receptors and Migration of TH17 Cell Subsets. In: Jiang, S. (eds) TH17 Cells in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9371-7_10

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