Abstract
Individuals suffering from a variety of cardiorespiratory diseases which are characterised by sustained or intermittent chronic hypoxia - such as chronic obstructive pulmonary disease, sleep apnoea, emphysema, congestive heart failure and stroke - often undergo pathological adaptation of tissue responses to acute hypoxia. Such a notion is supported experimentally by observations in chemosensing tissues such as the pulmonary vasculature, where voltage-gated K+ channel expression is selectively suppressed in chronic hypoxia (Smirnov et al 1994) and carotid body, where chronic hypoxia both in vitro (Stea et al 1992; Stea et al. 1995), and in vivo (Wyatt et al 1995; Eden & Hanson, 1987a; Eden & Hanson, 1987b) has been shown to modulate the acute cellular and whole-body hypoxic responses. Thus, it seems likely that remodelling of ion channel functional activity by sustained or intermittent episodes of hypoxia may underlie the responses to certain pathologies such as pulmonary hypertension (for recent reviews see Prabhakar, 2001; Prabhakar, 2002; Lanfranchi & Somers, 2001) in addition to the well documented adaptation to high altitude (Monge & Leon-Velarde, 1991).
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Ahring, P. K., Strobaek, D., Christophersen, P., Olesen, S. P., & Johansen, T. E., 1997, Stable expression of the human large-conductance Ca2+-activated K+ channel alpha-and alpha-and in HEK293 cells. FEBS Lett. 415, 67–70.
Eden, G. J. & Hanson, M. A., 1987a, Effects of chronic hypoxia from birth on the ventilatory response to acute hypoxia in the newborn rat. J.Physiol. 392, 11–19.
Eden, G. J. & Hanson, M A., 1987b, Maturation of the respiratory response to acute hypoxia in the newborn rat. J.Physiol. 392, 1–9.
Garcia-Calvo, M, Knaus, H. G., Garcia, M. L., Kaczorowski, G. J., & Kempner, E. S., 1994, Functional unit size of the charybdotoxin receptor in smooth muscle. Proc.NatlAcad.Sci.USA 91, 4718–4722.
Lan franchi, P. & Somers, V. K., 2001, Obstructive sleep apnea and vascular disease. Respir.Res. 2,315–319.
Lewis, A., Ashford, M. L. J. Ashford, C. Peers & P. J. Kemp, 2002, Hypoxia inhibits human recombinant maxi K+ channels by a mechanism which is membrane delimited and Ca2+-sensitive. J Physiol 540, 771–780.
Mojet, M. H., Mills, E., & Duchen, M. R., 1997, Hypoxia-induced catecholamine secretion in isolated newborn rat adrenal chromaffin cells is mimicked by inhibition of mitochondrial respiration. J.Physiol. 504, 175–189.
Monge, C. & Leon-Velarde, F., 1991, Physiological adaptation to high altitude: oxygen transport in mammals and birds. Physiol.Rev. 71, 1135–1172.
Prabhakar, N. R., 2001, Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms. J.AppLPhysiol. 90, 1986–1994.
Prabhakar, N. R., 2002, Sleep apneas: an oxidative stress? Am.J.Respir.Crit.Care Med. 165, 859–860.
Smirnov, S. V., Robertson, T. P., Ward, J. P. T., & Aarsonson, P. I., 1994, Chronic hypoxia is associated with reduced delayed rectifier K+ current in rat pulmonary artery muscle cells. AmJ.Physiol. 266, H365–H370.
Stea, A., Jackson, A., Macintyre, L., & Nurse, C. A., 1995, Long-term modulation of inward currents in 02 chemoreceptors by chronic hypoxia and cyclic AMP in vitro. Journal Of Neuroscience 15, 2192–2202.
Stea, A., Jackson, A., & Nurse, C. A., 1992, Hypoxia and N6, O2’-dibutyryladenosine 3’,5’-cyclic monophosphate, but not nerve growth factor, induce Na+ channels and hypertrophy in chromaffm-like arterial chemoreceptors. Proc.Natl.Acad.Sci. USA 89, 9469–9473
Wyatt, C. N., Wright, C, Bee, D., & Peers, C, 1995, O2-sensitive K+ currents in carotid-body chemoreceptor cells from normoxic and chronically hypoxic rats and their roles in hypoxic chemotransduction. Proc.Natl.Acad.Sci.USA 92, 295–299.
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Kemp, P.J., Hartness, M.E., Peers, C. (2003). Oxygen Sensing by Human Recombinant Large Conductance, Calcium-activated Potassium Channels. In: Pequignot, JM., Gonzalez, C., Nurse, C.A., Prabhakar, N.R., Dalmaz, Y. (eds) Chemoreception. Advances in Experimental Medicine and Biology, vol 536. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9280-2_73
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DOI: https://doi.org/10.1007/978-1-4419-9280-2_73
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