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Effect of Mitochondrial Inhibitors on Type I Cells

  • Christopher N. Wyatt
  • Keith J. Buckler
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 536)

Abstract

Inhibitors of mitochondrial function have been known to be stimulants of the carotid body for many decades. Recent experiments have demonstrated that in isolated neonatal rat type I cells both hypoxia and mitochondrial uncouplers inhibit background K+ currents. This leads to membrane depolarisation and voltage gated Ca2+ entry (Buckler, 1997; Buckler and Vaughan-Jones, 1998). Since these data are consistent with a role for mitochondria in oxygen sensing, we have determined whether other mitochondrial inhibitors mimic the effects of hypoxia on the type I cells.

Keywords

Intracellular Calcium Mitochondrial Function Membrane Depolarisation Carotid Body Patch Clamp Technique 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Buckler K.J. 1997, A novel oxygen-sensitive potassium current in rat carotid body type I cells. J. Physiol.; 498: 649–62PubMedGoogle Scholar
  2. Buckler K.J, Vaughan-Jones RD. 1998, Effects of mitochondrial uncouplers on intracellular calcium, pH and membrane potential in rat carotid body type I cells. J Physiol. ; 513 (Pt 3): 819–33.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Christopher N. Wyatt
    • 1
  • Keith J. Buckler
    • 1
  1. 1.University Laboratory of PhysiologyOxford

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