Abstract
Comroe and Schmidt (1938) proposed that decreasing PaO2is the effective stimulus for arterial chemoreceptors (aortic and carotid bodies), but they considered that these peripheral chemoreceptors could not play a role in the ventilatory control in normoxia. Nevertheless, electrophysiological recordings from the carotid (sinus) nerves showed chemoreceptor activity at normoxic PaO2, which became feeble or absent when the animal was made hyperoxic by breathing pure oxygen (Landgren and Zotterman, 1951; Åstrand, 1954).
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Fernández, R., Arriagada, I., Garrido, AM., Larraín, C., Zapata, P. (2003). Ventilatory Chemosensory Drive in Cats, Rats and Guinea-pigs. In: Pequignot, JM., Gonzalez, C., Nurse, C.A., Prabhakar, N.R., Dalmaz, Y. (eds) Chemoreception. Advances in Experimental Medicine and Biology, vol 536. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9280-2_62
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DOI: https://doi.org/10.1007/978-1-4419-9280-2_62
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