Abstract
Carbon dioxide is known to have a significant effect on the cardiovascular and respiratory systems mainly by an action within the central nervous system (CNS), possibly on chemosensitive neurons on the surface of the medulla (Somerset al.,1989). CO2is also known to activate peripheral chemoreceptors. There are many reports on cardiovascular responses to hypercapnia in various experimental settings (Marshall, 1986, Rose et al., 1983, Somers et al., 1989, Walker, 1987). Although most studies indicated an increase in arterial blood pressure (ABP) during hypercapnia, the results of heart rate (HR) response were conflicting. We have previously reported that hypercapnia elicited cardiovascular changes due to an increase in sympathetic nerve activity (SNA) by the direct effect of CO2 on CNS and a simultaneous increase in parasympathetic nerve activity via an activation of peripheral chemoreceptors during hypoxia (Hirakawa et al., 1997). However, there is only a little information regarding a role of peripheral chemoreceptors in autonomic regulation of the cardiovascular system during hypercapnia without an interaction of hypoxia. In this study, we examined autonomic nervous activity and cardiovascular responses in intact and chemo-denervated conscious rats during normoxic hypercapnia.
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Oikawa, S., Hirakawa, H., Kusakabe, T., Hayashida, Y. (2003). Effect of CO2 on Cardiovascular Regulation in Conscious Rats. In: Pequignot, JM., Gonzalez, C., Nurse, C.A., Prabhakar, N.R., Dalmaz, Y. (eds) Chemoreception. Advances in Experimental Medicine and Biology, vol 536. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9280-2_60
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DOI: https://doi.org/10.1007/978-1-4419-9280-2_60
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