Abstract
In vitro studies by Wiemann et al. (1999, 2001) have shown cultured CO2/H+ sensitive neurons from the ventrolateral medulla oblongata of newborn rats to enhance their bioelectric activity upon intracellular acidification induced by selective inhibition of the Na+/H+ exchanger type 3 (NHE-3). Recently, Kiwull- Schône et al. (2001) demonstrated the presence of NHE-3 mRNA in the adult rabbit brainstem, and likewise found NHE-3 immunoreactive neurons in brain-stem areas, which have prevalence for central chemosensitivity. The same study revealed that NHE-3 inhibition by the brain-permeant substance S8218 (Aventis Pharma) also significantly modified the central respiratory CO2-response of brain-stem in vivo.
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References
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Kiwull-Schône, H., Wiemann, M., Frede, S., Bingmann, D., Kiwull, P. (2003). Tentative Role of the Na+/H+ Exchanger Type 3 in Central Chemosensitivity of Respiration. In: Pequignot, JM., Gonzalez, C., Nurse, C.A., Prabhakar, N.R., Dalmaz, Y. (eds) Chemoreception. Advances in Experimental Medicine and Biology, vol 536. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9280-2_53
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DOI: https://doi.org/10.1007/978-1-4419-9280-2_53
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