Chemoreception pp 345-351 | Cite as

Contribution of Neural and Endothelial Isoforms of the Nitric Oxide Synthase to the Inhibitory Effects of NO on the Cat Carotid Body

  • Viviana Valdes
  • Matias Mosqueira
  • Rodrigo Iturriaga
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 536)


Nitric oxide (NO) produced within the carotid body (CB) is an inhibitory modulator of hypoxic chemoreception (Chugh et al., 1994; Wang et al., 1994, 1995; Iturriaga et al, 1998). Administration of NO donors and NO gas to the cat CB reduces the chemosensory response to hypoxia (Chugh et al., 1994; Iturriaga et al., 1998; Iturriaga et al, 2000b). Conversely, the inhibition of nitric oxide synthase (NOS) increases the frequency of carotid chemosensory discharges (f x) in the cat CB in situ and in vitro (Wang et al., 1994; Iturriaga et al., 1998). It has been proposed that NO produce vasodilatation in the CB (Chugh et al., 1994; Wang et al., 1994; Lahiri and Buerk, 1998), retrograde inhibition of glomus cell’s excitability (Wang et al., 1994), inhibition of glomus cell’s Ca+2 channels activity (Summers et al., 1999), modulation of petrosal ganglion neurons excitability (Alcayaga et al., 1997), and inhibition of mitochondrial metabolism (Iturriaga et al., 2000b). In the CB, the endothelial NOS (eNOS) is located in the endothelial cells and the neuronal (nNOS) in the sensory terminals of C fibers and parasympathetic neurons (Chugh et al., 1994; Wang et al, 1994, 1995).


Nitric Oxide Carotid Body Ventilatory Response Glomus Cell Hypoxic Ventilatory Response 
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  1. Alcayaga J., Iturriaga R, Ramirez J, Readi R, Quezada C, and Salinas S. 1997, Cat carotid body chemosensory response to non-hypoxic stimuli are inhibited by sodium nitroprusside both in situ and in vitro. Brain Res. 767: 384–387.CrossRefGoogle Scholar
  2. Chugh DK, Katayama M, Mokashi A, Debout DE, Ray DK, and Lahiri S. 1994, Nitric oxide-related inhibition of carotid chemosensory nerve activity in the cat. Resp. Physiol. 97: 147–156.CrossRefGoogle Scholar
  3. Gozal D, Gozal E, Gozal YM, and Torres JE. 1996, Nitric oxide synthase isoforms and peripheral chemoreceptor stimulation in conscious rats. Neuroreport 26: 1145–1148.CrossRefGoogle Scholar
  4. Iturriaga R, Alcayaga J, and Rey S. 1998, Sodium nitroprusside blocks the cat carotid chemosensory inhibition induced by dopamine, but not that by hyperoxia. Brain Res. 799: 26–34.PubMedCrossRefGoogle Scholar
  5. Iturriaga R, Villanueva S, and Mosqueira M. 2000a, Dual effects of nitric oxide on cat carotid body chemoreception. J.Appl. Physiol. 89: 1005–1012.Google Scholar
  6. Iturriaga R, Mosqueira M, and Villanueva S. 2000b, Effects of nitric oxide gas on carotid body chemosensory response to hypoxia. Brain Res. 855: 282–286.CrossRefGoogle Scholar
  7. Kline D, Yang T, Huang P, and Prabhakar NR. 1998, Altered response to hypoxia in mutant mice deficient in neuronal nitric oxide synthase J.Physiol. Lond.. 511: 273–287.PubMedCrossRefGoogle Scholar
  8. Kline D, Yang T, Huang P, Premkumar DR, Thomas AJ, and Prabhakar NR. 2000, Blunted respiratory responses to hypoxia in mutant mice deficient in nitric oxide synthase-3. J. Appl. Phvsiol. 88: 1496–1508.Google Scholar
  9. Lahiri S, and Buerk DG. 1998, Vascular and metabolic effects of nitric oxide synthase inhibition evaluated by tissue PO measurements in carotid body. Adv. Exp. Med. Biol. 454: 455–460.PubMedCrossRefGoogle Scholar
  10. Summers BA, Overholt JL, and Prabhakar, NR. 1999, Nitric oxide inhibits L-type Ca2+ current in glomus cells of the rabbit carotid body via a cGMP-independent mechanism.. Neurophysiol. 81: 1449–1457.Google Scholar
  11. Wang Z-Z, Stensaas LJ, Bredt DS, Dinger B, and Fidone SJ. 1994, Localization and actions of nitric oxide in the cat carotid body. Neuroscience 60: 275–286.PubMedCrossRefGoogle Scholar
  12. Wang Z-Z, Stensaas LJ, Dinger B, and Fidone SJ. 1995, Nitric oxide mediates chemoreceptor inhibition in the cat carotid body, Neuroscience 65; 217–229.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Viviana Valdes
    • 1
  • Matias Mosqueira
    • 1
  • Rodrigo Iturriaga
    • 1
  1. 1.Laboratorio de Neurobiología, Facultad de Ciencias BiológicasP. Universidad Católica de ChileSantiagoChile

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