Abstract
Nitric oxide (NO) produced within the carotid body (CB) is an inhibitory modulator of hypoxic chemoreception (Chugh et al., 1994; Wang et al., 1994, 1995; Iturriaga et al, 1998). Administration of NO donors and NO gas to the cat CB reduces the chemosensory response to hypoxia (Chugh et al., 1994; Iturriaga et al., 1998; Iturriaga et al, 2000b). Conversely, the inhibition of nitric oxide synthase (NOS) increases the frequency of carotid chemosensory discharges (f x) in the cat CB in situ and in vitro (Wang et al., 1994; Iturriaga et al., 1998). It has been proposed that NO produce vasodilatation in the CB (Chugh et al., 1994; Wang et al., 1994; Lahiri and Buerk, 1998), retrograde inhibition of glomus cell’s excitability (Wang et al., 1994), inhibition of glomus cell’s Ca+2 channels activity (Summers et al., 1999), modulation of petrosal ganglion neurons excitability (Alcayaga et al., 1997), and inhibition of mitochondrial metabolism (Iturriaga et al., 2000b). In the CB, the endothelial NOS (eNOS) is located in the endothelial cells and the neuronal (nNOS) in the sensory terminals of C fibers and parasympathetic neurons (Chugh et al., 1994; Wang et al, 1994, 1995).
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References
Alcayaga J., Iturriaga R, Ramirez J, Readi R, Quezada C, and Salinas S. 1997, Cat carotid body chemosensory response to non-hypoxic stimuli are inhibited by sodium nitroprusside both in situ and in vitro. Brain Res. 767: 384–387.
Chugh DK, Katayama M, Mokashi A, Debout DE, Ray DK, and Lahiri S. 1994, Nitric oxide-related inhibition of carotid chemosensory nerve activity in the cat. Resp. Physiol. 97: 147–156.
Gozal D, Gozal E, Gozal YM, and Torres JE. 1996, Nitric oxide synthase isoforms and peripheral chemoreceptor stimulation in conscious rats. Neuroreport 26: 1145–1148.
Iturriaga R, Alcayaga J, and Rey S. 1998, Sodium nitroprusside blocks the cat carotid chemosensory inhibition induced by dopamine, but not that by hyperoxia. Brain Res. 799: 26–34.
Iturriaga R, Villanueva S, and Mosqueira M. 2000a, Dual effects of nitric oxide on cat carotid body chemoreception. J.Appl. Physiol. 89: 1005–1012.
Iturriaga R, Mosqueira M, and Villanueva S. 2000b, Effects of nitric oxide gas on carotid body chemosensory response to hypoxia. Brain Res. 855: 282–286.
Kline D, Yang T, Huang P, and Prabhakar NR. 1998, Altered response to hypoxia in mutant mice deficient in neuronal nitric oxide synthase J.Physiol. Lond.. 511: 273–287.
Kline D, Yang T, Huang P, Premkumar DR, Thomas AJ, and Prabhakar NR. 2000, Blunted respiratory responses to hypoxia in mutant mice deficient in nitric oxide synthase-3. J. Appl. Phvsiol. 88: 1496–1508.
Lahiri S, and Buerk DG. 1998, Vascular and metabolic effects of nitric oxide synthase inhibition evaluated by tissue PO measurements in carotid body. Adv. Exp. Med. Biol. 454: 455–460.
Summers BA, Overholt JL, and Prabhakar, NR. 1999, Nitric oxide inhibits L-type Ca2+ current in glomus cells of the rabbit carotid body via a cGMP-independent mechanism.. Neurophysiol. 81: 1449–1457.
Wang Z-Z, Stensaas LJ, Bredt DS, Dinger B, and Fidone SJ. 1994, Localization and actions of nitric oxide in the cat carotid body. Neuroscience 60: 275–286.
Wang Z-Z, Stensaas LJ, Dinger B, and Fidone SJ. 1995, Nitric oxide mediates chemoreceptor inhibition in the cat carotid body, Neuroscience 65; 217–229.
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Valdes, V., Mosqueira, M., Iturriaga, R. (2003). Contribution of Neural and Endothelial Isoforms of the Nitric Oxide Synthase to the Inhibitory Effects of NO on the Cat Carotid Body. In: Pequignot, JM., Gonzalez, C., Nurse, C.A., Prabhakar, N.R., Dalmaz, Y. (eds) Chemoreception. Advances in Experimental Medicine and Biology, vol 536. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9280-2_45
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DOI: https://doi.org/10.1007/978-1-4419-9280-2_45
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