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Chemoreception pp 345-351 | Cite as

Contribution of Neural and Endothelial Isoforms of the Nitric Oxide Synthase to the Inhibitory Effects of NO on the Cat Carotid Body

  • Viviana Valdes
  • Matias Mosqueira
  • Rodrigo Iturriaga
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 536)

Abstract

Nitric oxide (NO) produced within the carotid body (CB) is an inhibitory modulator of hypoxic chemoreception (Chugh et al., 1994; Wang et al., 1994, 1995; Iturriaga et al, 1998). Administration of NO donors and NO gas to the cat CB reduces the chemosensory response to hypoxia (Chugh et al., 1994; Iturriaga et al., 1998; Iturriaga et al, 2000b). Conversely, the inhibition of nitric oxide synthase (NOS) increases the frequency of carotid chemosensory discharges (f x) in the cat CB in situ and in vitro (Wang et al., 1994; Iturriaga et al., 1998). It has been proposed that NO produce vasodilatation in the CB (Chugh et al., 1994; Wang et al., 1994; Lahiri and Buerk, 1998), retrograde inhibition of glomus cell’s excitability (Wang et al., 1994), inhibition of glomus cell’s Ca+2 channels activity (Summers et al., 1999), modulation of petrosal ganglion neurons excitability (Alcayaga et al., 1997), and inhibition of mitochondrial metabolism (Iturriaga et al., 2000b). In the CB, the endothelial NOS (eNOS) is located in the endothelial cells and the neuronal (nNOS) in the sensory terminals of C fibers and parasympathetic neurons (Chugh et al., 1994; Wang et al, 1994, 1995).

Keywords

Nitric Oxide Carotid Body Ventilatory Response Glomus Cell Hypoxic Ventilatory Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Viviana Valdes
    • 1
  • Matias Mosqueira
    • 1
  • Rodrigo Iturriaga
    • 1
  1. 1.Laboratorio de Neurobiología, Facultad de Ciencias BiológicasP. Universidad Católica de ChileSantiagoChile

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