Abstract
Update of the literature on Substance P and carotid body chemoreceptor function. Substance P was discovered in 1931 by Euler and Gaddum as a chemically unidentified substance present in dry acetone-powder extracts of the intestine and biologically characterized by its ability to contract smooth muscle and to lower arterial blood pressure as a result of vasodilatation. Recognized the presence of the same active principle in extracts of brain and spinal cord, substance P was finally identified chemically as an undecapeptide by Chang and Leeman in 1970. Soon after, radioimmunoassays and immunohistochemical methods were available to accurately study the distribution of the peptide in different tissues (see Euler and Pernow, 1977).
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Rico, A.J., Prieto-Lloret, J., Donnelly, D.F., Felipe, C.d., Gonzalez, C., Rigual, R. (2003). The Use of NK-1 Receptor Null Mice to Assess the Significance of Substance P in the Carotid Body Function.. In: Pequignot, JM., Gonzalez, C., Nurse, C.A., Prabhakar, N.R., Dalmaz, Y. (eds) Chemoreception. Advances in Experimental Medicine and Biology, vol 536. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9280-2_43
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