Chemoreception pp 327-336 | Cite as

The Use of NK-1 Receptor Null Mice to Assess the Significance of Substance P in the Carotid Body Function.

  • A. J. Rico
  • J. Prieto-Lloret
  • D. F. Donnelly
  • C. de Felipe
  • Constancio Gonzalez
  • R. Rigual
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 536)


Update of the literature on Substance P and carotid body chemoreceptor function. Substance P was discovered in 1931 by Euler and Gaddum as a chemically unidentified substance present in dry acetone-powder extracts of the intestine and biologically characterized by its ability to contract smooth muscle and to lower arterial blood pressure as a result of vasodilatation. Recognized the presence of the same active principle in extracts of brain and spinal cord, substance P was finally identified chemically as an undecapeptide by Chang and Leeman in 1970. Soon after, radioimmunoassays and immunohistochemical methods were available to accurately study the distribution of the peptide in different tissues (see Euler and Pernow, 1977).


Carotid Body Sensory Nerve Ending Hypoxic Ventilatory Response Chemoreceptor Cell Receptor Null Mouse 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • A. J. Rico
    • 1
  • J. Prieto-Lloret
    • 1
  • D. F. Donnelly
    • 1
  • C. de Felipe
    • 2
  • Constancio Gonzalez
    • 1
  • R. Rigual
    • 1
  1. 1.Depto. de Bioquímica y Biologia Molecular y Fisiología/(IBGM)Universidad de Valladolid /(CSIC). Facultad de Medicina. ValladolidAlicanteSpain
  2. 2.Instituto de NeurocienciasUniversidad Miguel Hernández/CSICAlicanteSpain

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