The Use of NK-1 Receptor Null Mice to Assess the Significance of Substance P in the Carotid Body Function.
Update of the literature on Substance P and carotid body chemoreceptor function. Substance P was discovered in 1931 by Euler and Gaddum as a chemically unidentified substance present in dry acetone-powder extracts of the intestine and biologically characterized by its ability to contract smooth muscle and to lower arterial blood pressure as a result of vasodilatation. Recognized the presence of the same active principle in extracts of brain and spinal cord, substance P was finally identified chemically as an undecapeptide by Chang and Leeman in 1970. Soon after, radioimmunoassays and immunohistochemical methods were available to accurately study the distribution of the peptide in different tissues (see Euler and Pernow, 1977).
KeywordsCarotid Body Sensory Nerve Ending Hypoxic Ventilatory Response Chemoreceptor Cell Receptor Null Mouse
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- Andoh, T., Itoh, H., Watanabe, I, Sasaki, T., and Higashi, T., 2001, Mechanisms of modulation of neuronal nicotinic receptors by substance P and OAG. Am. J. Physiol. Cell Physiol. 281:1871–1880.Google Scholar
- Clapham, D.E., and Neher, E., 1984 Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells. J. Physiol. 347:255–277.Google Scholar
- Euler, U. S., and Gaddum, J.H., 1931, An unidentified depressor substance in certain tissue extracts. JPhisiol. 72:74–87.Google Scholar
- Euler, U.S., and Pernow, B., 1977, Substance P Nobel Sympoium 37. Raven Press, New York.Google Scholar
- Fidone, S., and Gonzalez, C, 1986, Peripheral Chemoreceptors: Initiation and Control of Discharges. In Handbook of Physiology. The Respiratory System II (A.P. Fishman eds.), Amer. Physiol. Soc. Bethesda, Maryland, pp. 247.Google Scholar
- Fidone, S., Gonzalez, C, Obeso, A., Gomez Niño, A., and Dinger, B., 1990, Biogenic amine and neuropeptide transmitters in carotid body chemotransmission: Experimental Findings and Perspectives. In Hypoxia (J.R. Sutton et al.eds.) B.C. Decker Inc., Toronto, pp. 116.Google Scholar
- Heath D, Quinzanini M, Rodella A, Albertini A, Ferrari R, and Harris P., 1988, Immunoreactivity to various peptides in the human carotid body.Res. Commun. Chem. Pathol. Pharmacol. 62:2&9–293.Google Scholar
- Kusakabe, T., Kawakami, T., Tanabe, Y., Fujii, S., and Takenaka, T., 1994, Distribution of substance P-containing and catecholaminergic nerve fibers in the rabbit carotid body: an immunohistochemical study in combination with catecholamine fluorescent histochemistry. Arch. Histol. Cytol. 57:193–9.PubMedCrossRefGoogle Scholar
- McDonald, D.M., 1981, Peripheral chemoreceptors: Structure-function rationships or the carotid body. In Regulation of Breathing. Vol. 17. Lung Biology in Health and Disease (T.F. Hornbein and C. Lenfant, eds.), New York: Dekker, pp. 1–29.Google Scholar
- Vicario, I., Rigual, R., Obeso, A., & González, C, 2000, Characterization of the synthesis and release of catecholamine in the rat carotid body in vitro.Am. J. Physiol. 278:490–495Google Scholar