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Chemoreception pp 305-311 | Cite as

Adenosine-Acetylcholine Interactions at the Rat Carotid Body

  • Sílvia V. Conde
  • Emília C. Monteiro
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 536)

Abstract

Excitatory effects on carotid body (CB) chemotransduction have been described for adenosine and acetylcholine (ACh). The importance of the excitatory effects of exogenous (Monteiro and Ribeiro, 1987) and endogenous adenosine (Monteiro and Ribeiro, 1989) observed in vivo in the rat is supported by the increase in adenosine concentrations during hypoxia (Conde and Monteiro, 2001). In response to hypoxia, the CB also releases ACh (Fitzgerald et al. 1999) that activates nicotinic receptors (Shirahata et ai 1997). ACh and nicotine increase [Ca2+] in type I cells via activation of nicotinic receptors (Dasso et al 1997) and induce the release of several neurotransmitters at the CB, e.g. catecholamines (Obeso et ai 1997). In the present work we tested the hypothesis that ACh can induce the release of adenosine from rat carotid body by a mechanism that involves the activation of nicotinic receptors.

Keywords

Nicotinic Receptor Carotid Body Nicotinic Agonist Adenosine Concentration Nicotinic Antagonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Sílvia V. Conde
    • 1
  • Emília C. Monteiro
    • 1
  1. 1.Department of Pharmacology Faculty of Medical SciencesNew University of LisbonLisboaPortugal

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