Abstract
Excitatory effects on carotid body (CB) chemotransduction have been described for adenosine and acetylcholine (ACh). The importance of the excitatory effects of exogenous (Monteiro and Ribeiro, 1987) and endogenous adenosine (Monteiro and Ribeiro, 1989) observed in vivo in the rat is supported by the increase in adenosine concentrations during hypoxia (Conde and Monteiro, 2001). In response to hypoxia, the CB also releases ACh (Fitzgerald et al. 1999) that activates nicotinic receptors (Shirahata et ai 1997). ACh and nicotine increase [Ca2+] in type I cells via activation of nicotinic receptors (Dasso et al 1997) and induce the release of several neurotransmitters at the CB, e.g. catecholamines (Obeso et ai 1997). In the present work we tested the hypothesis that ACh can induce the release of adenosine from rat carotid body by a mechanism that involves the activation of nicotinic receptors.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alexander, S.P.H., Mathie, A. and Peters, J.A., 2001. TIPS Nomenclature Supplement 20th Edition, 1–12.
Cohen, G., Han, Z.Y., Grailhe, R., Gallego, J., Gaultier, C, Changeux, J.P. and Lagercrantz, H, 2002. p2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered breathing after nicotine exposure, PNAS 99:13272–13277.
Conde, S.V. and Monteiro, E.C, 2001. Hypoxia and extracellular pathway of adenosine production. Eur. J. Biochem. 268:67.
Conde, S.V. and Monteiro, E.C, 2002. Origin of adenosine released by the rat carotid body. XVth ISAC Symposium. Lyon (France).
Correia-de-S¨¢, P. and Ribeiro, J.A., 1994, Potentiation by tonic A2a-adenosine receptor activation of CGRP-facilitated [3H]- ACh release from rat motor nerve endings, Br.J.Pharmacol., 111: 582–588
Cunha, R.A., Milusheva, E., Vizi, E.S., Ribeiro, J.A. and Sebastião, A.M., 1994. Excitatory and inhibitory effects of Al and A2 adenosine receptor activation on the electrically evoked [3H] acetylcholine release from different areas of the rat hippocampus. J. Neurochem. 63:207–214.
Dasso, L.L.T., Buckler, K.J. and Vaughan-Jones, R.D., 1997. Muscarinic and nicotinic receptors raise intracellular Ca2+ levels in rat carotid body type I cells, J. Physiol. 498:327–338.
Fitzgerald, R.S., Shirahata, M. and Wang, H-Y., 1999. Acetylcholine release from cat carotid bodies, Brain Res., 841:53–61.
Ishizawa, Y., Fitzgerald, R.S., Shirahata, M. and Schofïeld, B., 1996. Localization of nicotinic acetylcholine receptors in cat carotid body and petrosal ganglion. Adv. Exp. Med. Biol. 410:253–256.
Monteiro, E.C. and Ribeiro, J.A., 1987. Ventilatory effects of adenosine mediated by carotid chemoreceptors in the rat. Naunyn-Schmiedeberg’s Arch. Pharmacol 335:143–148.
Monteiro, E.C. and Ribeiro, J.A., 1989. Adenosine deaminase and adenosine uptake inhibitors facilitate ventilation in rats. Naunyn-Schmiedeberg’s Arch. Pharmacol 340:230–238.
Nagayama, T., Matsumoto, T., Kuwakubo, F., Fukushima, Y., Yoshida, M., Suzuki-Kusaba, M., Hisa, H., Kimura, T. and Satoh, S., 1999, role of calcium channels in catecholamine secretion in the rat adrenal gland, J. Physiol 520: 503–512
Obeso, A., G¨®mez-Nino, M.A., Almaraz, L., Dinger, B., Fidone, S. and Gonzalez, C, 1997. Evidence for two types of nicotinic receptors in the cat carotid body chemoreceptor cells, Brain Res. 754:298–302.
Sabey, K., Paradiso, K., Zhang J. and Henry Steinbach, J., 1999. Ligand binding and activation of rat nicotinic a4p2 receptors stably expressed in HEK293 cells, Mol. Pharmacol 55:58–66.
Sebastião, A.M. and Ribeiro, J.A., 2000, Fine-tuning neuromodulation by adenosine, TIPS 21:341–346
Shirahata, M., Fitzgerald, R.S. and Sham, J.S.K., 1997. Acetylcholine increases intracellular calcium of arterial chemoreceptor cells of adult cats, J. Neurophysiol 78:2388–2395.
Zhang, M., Zhong, H., Vollmer, C. and Nurse, C.A., 2000, Co-release of ATP and ACh mediates hypoxic signaling at rat carotid body chemoreceptors. J. Physiol 525: 143–158
Zwart, R., van Kleef, R.G.D.M., Gotti, C, Smulders C.J.G.M. and Vijverberg, H.P.M., 2000. Competitive potentiation of acetylcholine effects on neuronal nicotinic receptors by acethylcholinesterase-inhibiting drugs, J.Neurochem. 75:2492–2500.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this paper
Cite this paper
Conde, S.V., Monteiro, E.C. (2003). Adenosine-Acetylcholine Interactions at the Rat Carotid Body. In: Pequignot, JM., Gonzalez, C., Nurse, C.A., Prabhakar, N.R., Dalmaz, Y. (eds) Chemoreception. Advances in Experimental Medicine and Biology, vol 536. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9280-2_40
Download citation
DOI: https://doi.org/10.1007/978-1-4419-9280-2_40
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4873-3
Online ISBN: 978-1-4419-9280-2
eBook Packages: Springer Book Archive