Abstract
Carotid body (CB) chemoreceptors are the major contributors to the hyperventilatory responses to acute hypoxia. Low PO2 inhibits K channel activity of chemoreceptor cells, inducing a depolarization-mediated neurotransmitter release that elicits the ventilatory response (Gonzalez et al, 1994). Although O2-sensitive K+ currents were described in rabbit CB chemoreceptor cells several years ago (López-Barneo et ai, 1988), the molecular identity of the underlying K channels remains unresolved.
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References
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© 2003 Springer Science+Business Media New York
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López-López, J.R., Pérez-GARCía, M.T., Sanz-Alfayate, G., Obeso, A., Gonzalez, C. (2003). Functional Identification of Kvα Subunits Contributing to the O2-Sensitive K+ Current in Rabbit Carotid Body Chemoreceptor Cells. In: Pequignot, JM., Gonzalez, C., Nurse, C.A., Prabhakar, N.R., Dalmaz, Y. (eds) Chemoreception. Advances in Experimental Medicine and Biology, vol 536. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9280-2_4
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DOI: https://doi.org/10.1007/978-1-4419-9280-2_4
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