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Functional Identification of Kvα Subunits Contributing to the O2-Sensitive K+ Current in Rabbit Carotid Body Chemoreceptor Cells

  • J. R. López-López
  • M. T. Pérez-GARCía
  • G. Sanz-Alfayate
  • Ana Obeso
  • Constancio Gonzalez
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 536)

Abstract

Carotid body (CB) chemoreceptors are the major contributors to the hyperventilatory responses to acute hypoxia. Low PO2 inhibits K channel activity of chemoreceptor cells, inducing a depolarization-mediated neurotransmitter release that elicits the ventilatory response (Gonzalez et al, 1994). Although O2-sensitive K+ currents were described in rabbit CB chemoreceptor cells several years ago (López-Barneo et ai, 1988), the molecular identity of the underlying K channels remains unresolved.

Keywords

Carotid Body Ventilatory Response Pipette Solution Acute Hypoxia Peak Current Amplitude 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • J. R. López-López
    • 1
  • M. T. Pérez-GARCía
    • 1
  • G. Sanz-Alfayate
    • 1
  • Ana Obeso
    • 1
  • Constancio Gonzalez
    • 1
  1. 1.Instituto de Biología y Genética Molecular (IBGM),Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas (CSIC); Departamento de Bioquímica y Biología Molecular y Fisiología, Facultad de MedicinaValladolidSpain

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