Functional Identification of Kvα Subunits Contributing to the O2-Sensitive K+ Current in Rabbit Carotid Body Chemoreceptor Cells
Carotid body (CB) chemoreceptors are the major contributors to the hyperventilatory responses to acute hypoxia. Low PO2 inhibits K channel activity of chemoreceptor cells, inducing a depolarization-mediated neurotransmitter release that elicits the ventilatory response (Gonzalez et al, 1994). Although O2-sensitive K+ currents were described in rabbit CB chemoreceptor cells several years ago (López-Barneo et ai, 1988), the molecular identity of the underlying K channels remains unresolved.
KeywordsCarotid Body Ventilatory Response Pipette Solution Acute Hypoxia Peak Current Amplitude
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- Sanchez, D., Lopez-Lopez, J. R., Perez-Garcia, M. T., Sanz-Alfayate, G., Obeso, A., Ganfornina, M. D., and Gonzalez, C. (2002). Molecular identification of Kvalpha subunits that contribute to the oxygen-sensitive K+ current of chemoreceptor cells of the rabbit carotid body. J Physiol (Lond) 542:369–382.CrossRefGoogle Scholar