Abstract
Hypoxic chemotransmission in the carotid body (CB) is mediated by the release of neurotransmitters (NTs) from type I cells onto adjacent sensory (petrosal) nerve endings (Gonzalez et al. 1994; Urena et al. 1994). In the rat, there is strong evidence of a role for the co-release of fast-acting neurotransmitters, including acetylcholine (ACh) and ATP (Zhang et al. 2000), in chemosensory signalling. In contrast, little is known about the roles of NTs in mediating autoreceptor feedback mechanisms which are thought to play a role in modulating chemoreceptor output from the CB. Here, we present evidence for the involvement of two distinct NTs, ¦Ã-aminobutyric acid (GABA) and serotonin (5-HT), in mediating autoreceptor feedback onto type I cells during hypoxia. Although their actions are directly opposite, activation of receptors for either transmitter appears to regulate the activity of O2-sensitive K+ channels, such as the background K+ channel Kcnk3 (Buckler et al. 2000). 5-HT receptor activation also regulates the activity of the O2-sensitive large-conductance Ca2+-activated K+ channel (Peers, 1990). These results demonstrate the roles of NTs in regulating secretion from type I cells, by converging signals from different sources onto the same K+ channels involved in O2 sensing and control of the receptor potential.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Barbe C et al. (2002).1234, J. Physiol., 543, 933–945.
Bowery N, Enna SJ (2000). 1234, J. Pharmacol. Exp. Ther., 2, 2–7.
Buckler KJ, Williams BA, Honore E (2000). 1234, J. Physiol., 525, 135–142.
E Silva M, Lewis DL (1995). 1234, J. Physiol. 489, 689–699.
Fearon IM et al. (1997). 1234,J. Physiol, 500, 551–556.
Fearon IM et al. (2002). 1234, J. Physiol, 545, 807–818.
Gonzalez C et al. (1994). 1234, Phys. Rev., 74, 829–898.
Lopes CMB, et al. (2000) 1234,J. Biol. Chem. 275, 16969–16978.
Maingret F et al. (2001) 1234, EMBO J. 20, 47–54.
Peers C (1990). 1234, Neurosci. Lett. 119, 253–256.
Prasad M et al. (2001). 1234, J. Physio.l, 537, 667–677.
Urena J et al. (1994). 1234, Proc. Natl Acad. Sci. U.S.A. 91, 10208–10211.
Zhang M et al.(2000). 1234, J. Physiol. 525, 143–158.
Zhong HJ, Zhang M, Nurse CA (1997). 1234, J. Physiol. 503, 599–612.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this paper
Cite this paper
Fearon, I.M., Zhang, M., Vollmer, C., Nurse, C.A. (2003). Expression and Function of Presynaptic Neurotransmitter Receptors in the Chemoafferent Pathway of the Rat Carotid Body. In: Pequignot, JM., Gonzalez, C., Nurse, C.A., Prabhakar, N.R., Dalmaz, Y. (eds) Chemoreception. Advances in Experimental Medicine and Biology, vol 536. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9280-2_39
Download citation
DOI: https://doi.org/10.1007/978-1-4419-9280-2_39
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4873-3
Online ISBN: 978-1-4419-9280-2
eBook Packages: Springer Book Archive