Cholinergic Actions on Carotid Chemosensory System
In simultaneous communications to the 15th International Congress of Physiological Sciences (Leningrad, 1935), Anichkovet aland Heymanset al.reported that intracarotid injections of acetylcholine (ACh) provoke reflex hyperventilation in cats and dogs, respectively (see Zapata, 1997b). The first evidence that ACh increases the frequency of chemosensory discharge(f x )of the carotid (sinus) nerve was provided by von Euleret al(1941). The attention on ACh as a stimulant of the arterial chemoreceptors (carotid bodies (CBs) and aortic bodies) became greater when the glomus cells of the CB were shown to synthesize and store ACh, which was released in response to hypoxia or electrical stimulation (Eyzaguirre and Zapata, 1968b).
KeywordsCarotid Body Cholinergic Action Glomus Cell Polygraphic Recording Nicotine Injection
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