Abstract
It is generally accepted that neurotransmitters are involved in hypoxic chemotransmission of the carotid body. The release of neurotransmitters from the glomus cell, a putative chemoreceptor cell, appears to be triggered by an influx of calcium and subsequent increase in intracellular calcium ([Ca2+]i). Several reports indicate that L-type and some other types of voltage-gated calcium channels are responsible for neurotranmitter release from glomus cells. Since these channels are activated by depolarization of the cell membrane, mechanisms of hypoxic depolarization of glomus cells has been a major focus of investigation (Shirahata and Sham, 1999).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Amato, A., Connolly, C.N., Moss, S.J., Smart, T.G., 1990, Modulation of neuronal and recombinant GABAA receptors by redox reagents, J. Physiol. 517: 35–50.
Andoh, T., Furuya, R., Oka, K., Hattori, S., Watanabe, I., Kamiya, Y., Okumura, F., 1997, Differential effects of thiopental on neuronal nicotinic acetylcholine receptors and P2X purinergic receptors in PC 12 cells, Anesthesiology 87: 1199–1209.
Chou, C.-L., Schofieid, B., Sham, J.S.K., Shirahata, M., 1998, Electrophysiological and immunological demonstration of cell-type specific responses to hypoxia in the adult cat carotid body, 789:229–238.
Dasso, L.L., Buckler, K.J., Vaughan-Jones, R.D., 1997, Muscarinic and nicotinic receptors raise intracellular Ca2+ levels in rat carotid body type I cells, J. Physiol. 498: 327–338.
Dinger, B., Gonzalez, C, Yoshizaki, K., Fidone, S., 1985, Localization and function of cat carotid body nicotinic receptors, Brain Res. 339: 295–304.
Gomez-Nino,A., Dinger,B., Gonzalez,C, Fidone,S.J., 1990, Differential stimulus coupling to dopamine and norepinephrine stores in rabbit carotid body type I cells, Brain Res. 525: 160–164.
Higashi, T., Yamaguchi, S., Mcintosh, J.M., and Shirahata, M., 2003, Nicotinic acetylcholine receptor channels in cat chemoreceptor cells, Adv. Exp. Med. Biol.
Ide, T., Shirahata, M., Chou, C.L., Fitzgerald, R.S., 1995, Effects of a continuous infusion of dopamine on the ventilatoiy and carotid body responses to hypoxia in cats, Clin. Exp. Pharmacol Physiol. 22: 658–664.
Lee, K., Ito, A., Koshimura, K., Ohue, T., Takagi, Y., Miwa, S., 1995, Differential effects of hypoxia on ligand binding properties of nicotinic and muscarinic acetylcholine receptors on cultured bovine adrenal chromaffin cells, J. Neurochem. 64: 874–882.
Oortgiesen, M., Leinders, T., Van Kleef, R.G., Vijverberg, H.P., 1993, Differential neurotoxicological effects of lead on voltage-dependent and receptor-operated ion channels, Neurotoxicology 14: 87–96.
Obeso, A., Gomez-Nino, M.A., Almaraz, L., Dinger, B., Fidone, S., Gonzalez, C, 1997, Evidence for two types of nicotinic receptors in the cat carotid body chemoreceptor cells, Brain Res. 754: 298–302.
Shirahata, M., Fitzgerald, R.S., Sham J.S.K., 1997, Acetylcholine increases intracellular calcium of arterial chemoreceptor cells of adult cats, J. Neurophysiol. 78: 2388–2395.
Shirahata, M., Sham, J.S.K., 1999, Roles of ion channels in carotid body chemotransmission of acute hypoxia, Jpn. J. Physiol. 49:213–228.
Tang, L.H., Aizenman, E., 1993, The modulation of N-methyl-D-aspartate receptors by redox and alkylating reagents in rat cortical neurones in vitro, J. Physiol. 465: 303–323.
Wade, J.A., Vaughan, P.F., Peers, C, 1998, Hypoxia enhances [3H]noradrenaline release evoked by nicotinic receptor activation from the human neuroblastoma SH-SY5Y, J. Neurochem. 71: 1482–1489.
Zwart, R., Abraham, D., Oortgiesen, M, Vijverberg, H.P., 1994, Alpha 4 beta 2 subunit combination specific pharmacology of neuronal nicotinic acetylcholine receptors in N1E- 115 neuroblastoma cells, Brain Res. 654: 312–318.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this paper
Cite this paper
Shirahata, M., Higashi, T., Mendoza, J.A., Hirasawa, S. (2003). Hypoxic Augmentation of Neuronal Nicotinic Acetylcholine Receptors and Carotid Body Function. In: Pequignot, JM., Gonzalez, C., Nurse, C.A., Prabhakar, N.R., Dalmaz, Y. (eds) Chemoreception. Advances in Experimental Medicine and Biology, vol 536. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9280-2_35
Download citation
DOI: https://doi.org/10.1007/978-1-4419-9280-2_35
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4873-3
Online ISBN: 978-1-4419-9280-2
eBook Packages: Springer Book Archive