ACH Differentially Modulates Voltage-gated K Channels in Glomus Cells between DBA/2J and A/J Strains of Mice
The hypoxic ventilatory response (HVR) among individuals varies widely (Eisele et al, 1992; Vizek et al, 1987; Weil et al, 1970) and genetic factors significantly contribute to these variations (Kawakami et al, 1982; Nishimura et al, 1991). A study using several inbred strains of mice indicates that genetic determinants apparently influence the HVR (Tankersley et al, 1994) DBA/2J mice demonstrated the highest HVR and the A/J mice the lowest HVR. These data suggest that genetically regulated differences exist in the system controlling the hypoxic ventilatory response. A major hypoxic chemosensor is the carotid body. Recently, we have found morphological and functional differences in glomus cells between DBA/2J and A/J mice (Yamaguchi et al, 2003). The carotid body of DBA/2J mice contain more glomus cells than that of the A/J mice, and more glomus cells in DBA/2J mice increase intracellular Ca2+ in response to ACh than those in A/J mice.
KeywordsCarotid Body Outward Current Krebs Solution Patch Clamp Experiment Glomus Cell
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