Chemoreception pp 263-268 | Cite as

ACH Differentially Modulates Voltage-gated K Channels in Glomus Cells between DBA/2J and A/J Strains of Mice

  • Shigeki Yamaguchi
  • Tomoko Higashi
  • Yuichi Hori
  • Machiko Shirahata
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 536)


The hypoxic ventilatory response (HVR) among individuals varies widely (Eisele et al, 1992; Vizek et al, 1987; Weil et al, 1970) and genetic factors significantly contribute to these variations (Kawakami et al, 1982; Nishimura et al, 1991). A study using several inbred strains of mice indicates that genetic determinants apparently influence the HVR (Tankersley et al, 1994) DBA/2J mice demonstrated the highest HVR and the A/J mice the lowest HVR. These data suggest that genetically regulated differences exist in the system controlling the hypoxic ventilatory response. A major hypoxic chemosensor is the carotid body. Recently, we have found morphological and functional differences in glomus cells between DBA/2J and A/J mice (Yamaguchi et al, 2003). The carotid body of DBA/2J mice contain more glomus cells than that of the A/J mice, and more glomus cells in DBA/2J mice increase intracellular Ca2+ in response to ACh than those in A/J mice.


Carotid Body Outward Current Krebs Solution Patch Clamp Experiment Glomus Cell 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Shigeki Yamaguchi
    • 1
    • 2
  • Tomoko Higashi
    • 1
  • Yuichi Hori
    • 3
  • Machiko Shirahata
    • 1
  1. 1.Departments of Environmental Health SciencesJohns Hopkins Bloomberg School of Public HealthBaltimoreUSA
  2. 2.Department of AnesthesiologyDokkyo University School of MedicineMibuJapan
  3. 3.Department of PhysiologyDokkyo University School of MedicineMibuJapan

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