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Chemoreception pp 209-215 | Cite as

Oxygen Sensing by Human Recombinant Large Conductance,Calcium-activated Potassium Channels

Regulation by acute hypoxia
  • Paul J. Kemp
  • Chris Peers
  • Anthony Lewis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 536)

Abstract

Although O2-sensitive tissues express a wide variety of channel types (Lopez-Barneo et al. 2001; Peers & Kemp, 2001), central to the cellular mechanism of O2 sensing in many is hypoxic suppression of large conductance Ca2+-activated K+ channels (maxiK, BKCa or Slo channels). Thus, hypoxic inhibition of maxiK channels has been demonstrated in carotid body (Peers, 1990; Pardal et al. 2000; Riesco-Fagundo et al. 2001), pulmonary smooth muscle (Cornfield et al. 1996), chromaffin cells (Thompson & Nurse, 1998), and other non-chemosensory tissues such as central neurones (Liu et al. 1999; Jiang & Haddad, 1994b). Contribution of this channel type to carotid body, chromatin cell and central neuronal function is well supported although some controversy still surrounds their involvement in pulmonary vasoconstriction (Ward & Aaronson, 1999) where there is also good evidence for both delayed rectifier (Tristani-Firouzi et al. 1996) and tandem P domain K+ channels in the response (Gurney et al. 2002); the later observation is fully supported by our recent report of O2 sensitivity of the tandem P domain channel, hTASKl, in a recombinant mammalian system similar to that employed in the present study (Lewis et al., 2001).

Keywords

Carotid Body Acute Hypoxia Pulmonary Artery Smooth Muscle Cell Asymmetrical Solution Cytosolic Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Paul J. Kemp
    • 1
  • Chris Peers
    • 2
  • Anthony Lewis
    • 1
  1. 1.School of Biomedical SciencesUniversity of LeedsUK
  2. 2.Institute for Cardiovascular Research, Worsley Medical and Dental BuildingUniversity of LeedsUK

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