Chemoreception pp 209-215 | Cite as

Oxygen Sensing by Human Recombinant Large Conductance,Calcium-activated Potassium Channels

Regulation by acute hypoxia
  • Paul J. Kemp
  • Chris Peers
  • Anthony Lewis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 536)


Although O2-sensitive tissues express a wide variety of channel types (Lopez-Barneo et al. 2001; Peers & Kemp, 2001), central to the cellular mechanism of O2 sensing in many is hypoxic suppression of large conductance Ca2+-activated K+ channels (maxiK, BKCa or Slo channels). Thus, hypoxic inhibition of maxiK channels has been demonstrated in carotid body (Peers, 1990; Pardal et al. 2000; Riesco-Fagundo et al. 2001), pulmonary smooth muscle (Cornfield et al. 1996), chromaffin cells (Thompson & Nurse, 1998), and other non-chemosensory tissues such as central neurones (Liu et al. 1999; Jiang & Haddad, 1994b). Contribution of this channel type to carotid body, chromatin cell and central neuronal function is well supported although some controversy still surrounds their involvement in pulmonary vasoconstriction (Ward & Aaronson, 1999) where there is also good evidence for both delayed rectifier (Tristani-Firouzi et al. 1996) and tandem P domain K+ channels in the response (Gurney et al. 2002); the later observation is fully supported by our recent report of O2 sensitivity of the tandem P domain channel, hTASKl, in a recombinant mammalian system similar to that employed in the present study (Lewis et al., 2001).


Carotid Body Acute Hypoxia Pulmonary Artery Smooth Muscle Cell Asymmetrical Solution Cytosolic Factor 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Paul J. Kemp
    • 1
  • Chris Peers
    • 2
  • Anthony Lewis
    • 1
  1. 1.School of Biomedical SciencesUniversity of LeedsUK
  2. 2.Institute for Cardiovascular Research, Worsley Medical and Dental BuildingUniversity of LeedsUK

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