Amyloid Peptide-Mediated Hypoxic Regulation of Ca2+ Channels in PC12 Cells
The incidence of dementias such as Alzheimer’s Disease (AD) is dramatically increased in patients who have previously suffered prolonged hypoxic or ischemic episodes. Such episodes commonly arise as a consequence of cardiovascular dysfunctions such as stroke (Tatemichi et al. 1994; Kokmen et al. 1996; Moroney et al. 1996). This clear link between hypoxic/ischemic episodes and increased incidence of AD strongly suggests that reduction in local O2 levels may be capable of precipitating this increasingly widespread disease.
KeywordsPC12 Cell Chronic Hypoxia Amyloid Peptide Ischemic Episode Influx Pathway
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