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Chemoreception pp 187-192 | Cite as

Amyloid Peptide-Mediated Hypoxic Regulation of Ca2+ Channels in PC12 Cells

  • Chris Peers
  • Kim N. Green
  • John P. Boyle
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 536)

Abstract

The incidence of dementias such as Alzheimer’s Disease (AD) is dramatically increased in patients who have previously suffered prolonged hypoxic or ischemic episodes. Such episodes commonly arise as a consequence of cardiovascular dysfunctions such as stroke (Tatemichi et al. 1994; Kokmen et al. 1996; Moroney et al. 1996). This clear link between hypoxic/ischemic episodes and increased incidence of AD strongly suggests that reduction in local O2 levels may be capable of precipitating this increasingly widespread disease.

Keywords

PC12 Cell Chronic Hypoxia Amyloid Peptide Ischemic Episode Influx Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Chris Peers
    • 1
  • Kim N. Green
    • 1
  • John P. Boyle
    • 1
  1. 1.Institute for Cardiovascular Research, Worsley Medical and Dental BuildingUniversity of LeedsUK

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