Effect of HERG-like Potassium Channel Blocker on the Carotid Body Chemoreception
It has been hypothesized that an oxygen sensitive K+ channel (KO2) on the glomus cell plays a central role in hypoxic chemoreception (López- Barneo et al., 1988). This hypothesis, known as “the membrane model”, states that hypoxia inhibits conductance of the KO2 channel, leading to depolarization of the cell membrane. Subsequently, the depolarization induces opening of voltage-dependent Ca2+ channels and the resultant Ca2+ influx. Finally, released neurotransmitters stimulate the terminals of afferent fibers (López-Barneo, 1996).
KeywordsCarotid Body Free Solution Glomus Cell Potassium Channel Blocker Carotid Sinus Nerve
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