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Chemoreception pp 117-122 | Cite as

Effect of HERG-like Potassium Channel Blocker on the Carotid Body Chemoreception

  • Shinobu Osanai
  • Toru Takahashi
  • Hitoshi Nakano
  • Yoshinobu Ohsaki
  • Kenjiro Kikuchi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 536)

Abstract

It has been hypothesized that an oxygen sensitive K+ channel (KO2) on the glomus cell plays a central role in hypoxic chemoreception (López- Barneo et al., 1988). This hypothesis, known as “the membrane model”, states that hypoxia inhibits conductance of the KO2 channel, leading to depolarization of the cell membrane. Subsequently, the depolarization induces opening of voltage-dependent Ca2+ channels and the resultant Ca2+ influx. Finally, released neurotransmitters stimulate the terminals of afferent fibers (López-Barneo, 1996).

Keywords

Carotid Body Free Solution Glomus Cell Potassium Channel Blocker Carotid Sinus Nerve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Shinobu Osanai
    • 1
  • Toru Takahashi
    • 1
  • Hitoshi Nakano
    • 1
  • Yoshinobu Ohsaki
    • 1
  • Kenjiro Kikuchi
    • 1
  1. 1.First Department of MedicineAsahikawa Medical College 2-1-1-1 Midorigaoka HigashiAsahikawaJapan

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