Abstract
In the mid-fifties, Dejours became interested in the contribution of the arterial chemoreceptors in the regulation of breathing in humans. The role, but not the intimate mechanisms, of the receptors was relatively well known thanks to the experiments of recording of afferent activity and of electrical stimulation or denervation of afferent nerves but, for obvious reasons, these experiments could not be performed in humans. Human beings are provided with the same chemosensitive structures as laboratory animals and the fact that functional responses to respiratory stimuli (hypoxia and/or hypercapnia) are about the same in humans and experimental animals makes it likely that in human beings, the part played by the reflexogenic drive is the same as in animals.
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References
Bisgard, G.E., and Neubauer, J.A., 1995, Peripheral and central effects of hypoxia. In Regulation of Breathing (S.A. Dempsey and A.I. Pack, eds), Marcel Dekker, Inc, New York, pp. 617–668.
Bouverot, P., Flandrois, R., Pucinelli, R., and Dejours, P., 1965, Etude du rôle des chémorécepteurs artériels dans la régulation de la respiration pulmonaire chez le chien éveillé. Arch. Int. Pharmac.Thérap. 157 : 257–271.
Bouverot, P., and Leitner, L.-M, 1972, Arterial chemorecptors in the domestic fowl. Respir. Physiol 15: 310–320.
Dejours, P., 1957, Intérêt méthodologique de l’étude d’un organisme vivant à la phase initiale de rupture d’un équilibre physiologique. Compt. Rend. Acad. Sci. Paris 245 : 1946–1948.
Dejours, P., 1962, Chemoreflexes in breathing. Physiol. Rev. 42 : 335–358.
Dejours, P., Girard, F., Labrousse, Y., and Teillac, A., 1959, Etude de la régulation ventilation de repos chez l’Homme en haute altitude. Rev. Fr. Etudes Clin. Biol. 4 : 115–127.
Dejours, P., Labrousse, Y., Raynaud, J., and Flandrois, R., 1958a, Etude du stimulus gaz carbonique de la ventilation chez l’Homme. J. Physiol. Paris 50: 239–243.
Dejours, P., Labrousse, Y., Raynaud, J., Girard, F., and Teillac, A., 1958b, Stimulus oxygène de la ventilation au repos et au cours de l’exercice musculaire, à basse altitude (50m), chez l’Homme. Rev. Fr. Etudes Clin. Biol. 3 : 105–123.
Dejours, P., Labrousse, Y., Raynaud, J., and Teillac, A., 1957, Stimulus oxygène chémoréfîexe de la ventilation à basse altitude (50m) chez l’Homme. I Au repos. J. Physiol. Paris 49 : 115–124.
Dripps, R.D., and Comroe, J.H., Jr, 1947, The effect of the inhalation of high and low oxygen concentrations on respiration, pulse rate, ballisto-cardiogram and arterial oxygen saturation oximeter) of normal individuals. Amer. J. Physiol. 149 : 277–291.
Easton, P. A., Slykerman, L.J., and Anthonisen, N.R., 1986, Ventilatory response to sustained hypoxia in normal adults. J. Appl. Physiol. 61 : 906–911.
Easton, P.A., Slykerman, L.J., and Anthonisen, N.R., 1988, Recovery of the ventilatory response to hypoxia in normal adults. J. Appl. Physiol. 64 : 521–528.
Gautier, H., Bonora, M., Gaudy, J.H., 1986, Ventilatory response of the conscious or anesthetized cat to oxygen breathing. Respir. Physiol. 65 : 181–196.
Girard, F., Lacaisse, A., and Dejours, P., 1960, Le stimulus O2 ventilatoire à la période néonatale chez l’Homme. J. Physiol. Paris 52 : 108–109.
Girard, F., Teillac, A., Lefrançois, R., and Lacaisse, A., 1959, Etude du stimulus oxygène de la ventilation en hypoxie aiguë. J. Physiol. Paris 51 : 469–470.
Gozal, D., 1998, Potentiation of hypoxic ventilatory response by hyperoxia in the conscious rat :putative role of nitric oxide. J. Appl. Physiol. 85 : 129–132.
Guz, A., Noble, M.I.M., Widdicombe, J.G., Trenchard, D., and Mushin, W.W., 1966, Peripheral chemoreceptor block in man. Respir. Physiol 1 : 38–40.
Honda, Y., Tani, H., Masuda, A., Kobayashi, T., Nishino, T., Kimura, H., Masuyama, S., and Kuriyama, T., 1996, Effect of prior O2 breathing on ventilatory response to sustained isocapnic hypoxia in adult humans. J. Appl. Physiol. 81 : 1627–1632.
Lefrançois, R., Gautier, H., and Pasquis, P., 1968, Ventilatory oxygen drive in acute and chronic hypoxia. Respir. Physiol. 4 : 217–228.
Leitner, L.-M., Pagès, B., Pucinelli, R., and Dejours, P., 1965, Etude simultanée de la ventilation et des décharges des chémorécepteurs du glomus carotidien chez le chat. 1 Au cours d’inhalations brèves d’oxygène pur. Arch. Int. Pharmac. Thérap. 154 : 421–426.
Loeschcke, G.C., 1953, Spielen für die Ruheatmung des Menschen vom 02-Druck abhängige Erregungen des Chemoreceptoren eine Rolle ? Arch. ges.Physiol. 257 : 349–362.
May, P., 1957, L’action immédiate de l’oxygène sur la ventilation chez l’homme normal. Helv. Physiol. Acta 15 : 230–240.
Miller, M.J., and Tenney, S.M., 1975, Hyperoxic hyperventilation in carotid-deafferented cats Respir. Physiol. 23 : 23–30.
Mortola, J.P., and Gautier, H., 1995, Interaction between metabolism and ventilation : Effects of respiratory gases and temperature. In Regulation of Breathing (J.A. Dempsey and A.I. Pack, eds), Marcel Dekker, Inc, New York, pp. 1011–1064.
Roux, J.C., Peyronnet, J., Pascual, O., Dalmaz, Y., and Péquignot, J.C., 2000, Ventilatory and central neurochemical reorganisation of O2 chemoreflex after carotid sinus nerve transection in rat. J. Physiol. London 522 : 493–501.
Shock, N.W., and Soley, M.H., 1940, Effect of breathing pure oxygen on respiratory volume in humans. Proc. Soc. Exp. Biol. Med. 44 : 418–420.
Subramanian, S., Erokwu, B., Han, F., Dick, T.E., and Strohl, K.P., 2002, L-NAME differentially alters ventilatory behavior in Sprague-Dawley and Brown Norway rats. J. Appl. Physiol. 93 : 984–989.
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Gautier, H. (2003). Honoring Pierre Dejours : His Contribution to the Study of the Role of the Arterial Chemoreceptors in the Regulation of Breathing in Humans. In: Pequignot, JM., Gonzalez, C., Nurse, C.A., Prabhakar, N.R., Dalmaz, Y. (eds) Chemoreception. Advances in Experimental Medicine and Biology, vol 536. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9280-2_1
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