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Autoimmunity in Cardiomyopathies

  • Chapter
Cardiomyopathies and Heart Failure

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 248))

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Abstract

Among various forms of cardiomyopathies, dilated cardiomyopathy has a multifactorial etiology and pathogenicity, its socioeconomic impact is major, and it represents the leading indication for heart transplantation.1 The pathogenic relationship between viral-induced chronic inflammation and dilated cardiomyopathy may best be illustrated by the meta-analytical observation of the evolution of 21% of acute cases of myocarditis to dilated cardiomyopathy within 33 months of follow-up.2 The prognosis of dilated cardiomyopathy remains grave with conventional pharmacological management, which does not consider the underlying pathogenesis.3 Numerous pathogenically significant autoantibodies directed against cryptic myocardial antigens have been identified in patients with dilated cardiomyopathy. Immunohistochemical quantitative analysis of intramyocardial inflammation and refined molecular biological techniques have begun a new era in the diagnosis of intramyocardial inflammation and viral infection, leading to the description of a new specific disease entity, the inflammatory cardiomyopathy, endorsed by the World Health Organization Task Force on the Definition and Classification of Cardiomyopathies. The etiologic and pathogenic differentiation of dilated cardiomyopathy with reference to inflammation, with or without viral persistence, has fostered promising concepts toward scientifically based treatment modalities.

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Authors and Affiliations

  1. Department of Cardiology and Pneumonology, University Hospital Benjamin Franklin, Free University of Berlin, Germany

    Michel Noutsias MD, Matthias Pauschinger MD, Uwe Kuhl PhD & Heinz-Peter Schultheiss MD

Authors
  1. Michel Noutsias MD
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  2. Matthias Pauschinger MD
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  3. Uwe Kuhl PhD
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  4. Heinz-Peter Schultheiss MD
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Editors and Affiliations

  1. Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Akira Matsumori MD, PhD

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Noutsias, M., Pauschinger, M., Kuhl, U., Schultheiss, HP. (2003). Autoimmunity in Cardiomyopathies. In: Matsumori, A. (eds) Cardiomyopathies and Heart Failure. Developments in Cardiovascular Medicine, vol 248. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9264-2_7

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  • DOI: https://doi.org/10.1007/978-1-4419-9264-2_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4865-8

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