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Detection and Biological Implications of Genetic Memory in Viral Quasispecies

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Cardiomyopathies and Heart Failure

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 248))

Abstract

Infection of an organism or cells in culture with a single infectious genome of an RNA virus results in the prompt formation of a spectrum of mutants, as has been experimentally documented with representatives of the major groups of RNA virus pathogens.1 This fact is critical for the understanding of viral pathogenesis, since it means that a virus does not exist as a genetically defined entity but rather as a distribution of genomes which differ from each other in one or several positions in their nucleotide sequence (figure 1). Some of these closely related but non-identical genomes may have biological properties which differ from those of the average viral population or from those of other components of the mutant spectrum. Thus, genetic heterogeneity is paralleled by a phenotypic heterogeneity in viral populations. Well documented examples are the presence in mutant spectra of variants with altered antigenicity, host cell tropism, capacity to induce interferon, decreased sensitivity to antiviral inhibitors, or variants which display altered patterns of viral gene expression (specific examples and reviews in refs. 2-13).

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Authors and Affiliations

  1. Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Universidad Autónoma de Madrid, Cantoblanco, 28049, Madrid, Spain

    Esteban Domingo PhD, Carmen M. Ruiz-Jarabol PhD, Armando Ariasl BSc, Cristina Escarmís PhD & Eric Baranowski PhD

  2. Mathematics Institute, University of Warwick, CV4 7AL, Coventry, UK

    Esteban Domingo PhD, Carmen Molina-París PhD & Carlos Briones PhD

  3. CISA-lNIA, Valdeolmos, 28130, Madrid, Spain

    Eric Baranowski PhD

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  1. Esteban Domingo PhD
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Editors and Affiliations

  1. Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Akira Matsumori MD, PhD

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Domingo, E. et al. (2003). Detection and Biological Implications of Genetic Memory in Viral Quasispecies. In: Matsumori, A. (eds) Cardiomyopathies and Heart Failure. Developments in Cardiovascular Medicine, vol 248. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9264-2_21

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