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Cardiac Remodeling and Failure pp 67–74Cite as

The Failing SHHF Rat Heart

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Part of the book series: Progress in Experimental Cardiology ((PREC,volume 5))

Abstract

The SHHF/Mccfa cp (SHHF) rat is a reliable genetic model of congestive heart failure secondary to essential hypertension. These animals are closely related to the SHR (spontaneously hypertensive rat), but unlike the SHR, all animals, male and female, develop fatal congestive heart failure, most in the second year of life. SHHF rats are now being widely used by the pharmaceutical industry to evaluate potential therapeutic agents for preventing the maladaptive ultrastructural and biochemical remodeling associated with cardiac hypertrophy and the progression to failure. SHHF rats have also proved to be useful for mechanistic studies of the contractile and signaling abnormalities associated with heart failure. The failing SHHF rat heart is hypertrophied, dilated, fibrotic, and exhibits a pronounced decline in fractional shortening in vivo as measured by M-mode echocardiography. The response to ß-adrenoceptor stimulation is markedly blunted; there is evidence to suggest a decline in excitation-contraction coupling gain; and there is a decline in maximal Ca2+ activated force per cross sectional area. Isolated perfused failing SHHF hearts exhibit a predisposition to develop mechanical alternans, a negative force-frequency response and altered electromechanical restitution. Comparable abnormalities are seen in human heart failure, making the SHHF rat an ideal small animal model for investigating the natural history of cardiac hypertrophy, the transition to failure, and the unique properties of the failing myocardium.

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Authors and Affiliations

  1. Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH, 43210, USA

    Ruth A. Altschuld Ph.D., Bethany J. Holycross, M. Judith Radin & Sylvia A. McCune

Authors
  1. Ruth A. Altschuld Ph.D.
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  2. Bethany J. Holycross
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  3. M. Judith Radin
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  4. Sylvia A. McCune
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Corresponding author

Correspondence to Ruth A. Altschuld Ph.D. .

Editor information

Editors and Affiliations

  1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Pawan K. Singal PhD, DSc (Professor), Ian M. C. Dixon PhD (Associate Professor), Lorrie A. Kirshenbaum PhD (Associate Professor) & Naranjan S. Dhalla PhD, MD (HON), DSc (HON) (Distinguished Professor and Director) (Professor),  (Associate Professor),  (Associate Professor) &  (Distinguished Professor and Director)

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© 2003 Springer Science+Business Media New York

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Altschuld, R.A., Holycross, B.J., Radin, M.J., McCune, S.A. (2003). The Failing SHHF Rat Heart. In: Singal, P.K., Dixon, I.M.C., Kirshenbaum, L.A., Dhalla, N.S. (eds) Cardiac Remodeling and Failure. Progress in Experimental Cardiology, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9262-8_4

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  • DOI: https://doi.org/10.1007/978-1-4419-9262-8_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4864-1

  • Online ISBN: 978-1-4419-9262-8

  • eBook Packages: Springer Book Archive

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