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Is an Intracrine Renin-Angiotensin System Involved in the Control of Cardiovascular Function?

  • Chapter
Cardiac Remodeling and Failure

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 5))

Abstract

We review the evidence that there is an intracrine renin angiotensin system in the heart and vessels which contributes to the regulation of cardiovascular function. Angiotensin II, like a variety of other peptide hormones, has been shown to bind to intracellular receptors after either internalization or intracellular synthesis. The evidence of an intracrine action of Ang II on regulation of heart cell coupling and contractility as well as in cardiovascular pathology is discussed.

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Authors and Affiliations

  1. Department of Pharmacology, Medical Sciences, Campus UPR, San Juan, Puerto Rico, 00936-5067, USA

    Dr. Walmor C. De Mello

  2. Research Division, Alton Ochnser Medical Foundation, New Orleans, Louisiana

    Richard N. Re

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  1. Dr. Walmor C. De Mello
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Correspondence to Walmor C. De Mello .

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Editors and Affiliations

  1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Pawan K. Singal PhD, DSc (Professor), Ian M. C. Dixon PhD (Associate Professor), Lorrie A. Kirshenbaum PhD (Associate Professor) & Naranjan S. Dhalla PhD, MD (HON), DSc (HON) (Distinguished Professor and Director) (Professor),  (Associate Professor),  (Associate Professor) &  (Distinguished Professor and Director)

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De Mello, W.C., Re, R.N. (2003). Is an Intracrine Renin-Angiotensin System Involved in the Control of Cardiovascular Function?. In: Singal, P.K., Dixon, I.M.C., Kirshenbaum, L.A., Dhalla, N.S. (eds) Cardiac Remodeling and Failure. Progress in Experimental Cardiology, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9262-8_26

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  • DOI: https://doi.org/10.1007/978-1-4419-9262-8_26

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