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Infarct Scar. Living Tissue

  • Chapter
Cardiac Remodeling and Failure

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 5))

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Abstract

Heart failure, a worldwide health problem, is most commonly due to ischemic cardiomyopathy (ICM) with previous myocardial infarction(s). Herein, insights into the infarct scar as living tissue (and which resembles heart valve leaflets) are reviewed. This includes: a) its population of persistent, metabolically active myofibroblasts, whose elaboration of angiotensin II regulates (via AT1 receptor-ligand binding) their production of TGF-β1 and, in turn, type I fibrillar collagen; b) its neovasculature, which nourishes these fibroblast-like cells; and c) its contractile tonus. Scar tissue myofibroblasts regulate the accumulation of collagen found at sites remote to the infarct and it is this interstitial fibrosis that represents a major component to the adverse structural remodeling seen in ICM. The management of heart failure due to ICM therefore needs to take into account the behavior of infarct scar myofibroblasts.

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Authors and Affiliations

  1. Division of Cardiovascular Diseases Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA

    Karl T. Weber M.D.

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  1. Karl T. Weber M.D.
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Correspondence to Karl T. Weber M.D. .

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Editors and Affiliations

  1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Pawan K. Singal PhD, DSc (Professor), Ian M. C. Dixon PhD (Associate Professor), Lorrie A. Kirshenbaum PhD (Associate Professor) & Naranjan S. Dhalla PhD, MD (HON), DSc (HON) (Distinguished Professor and Director) (Professor),  (Associate Professor),  (Associate Professor) &  (Distinguished Professor and Director)

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Weber, K.T. (2003). Infarct Scar. Living Tissue. In: Singal, P.K., Dixon, I.M.C., Kirshenbaum, L.A., Dhalla, N.S. (eds) Cardiac Remodeling and Failure. Progress in Experimental Cardiology, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9262-8_23

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  • DOI: https://doi.org/10.1007/978-1-4419-9262-8_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4864-1

  • Online ISBN: 978-1-4419-9262-8

  • eBook Packages: Springer Book Archive

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