Calreticulin pp 105-125 | Cite as

Modulation of Calcium Homeostasis by the Endoplasmic Reticulum in Health and Disease

  • György Szabadkai
  • Mounia Chami
  • Paolo Pinton
  • Rosario Rizzuto
Part of the Molecular Biology Intelligence Unit book series (MBIU)


The endoplasmic reticulum (ER) is the main intracellular agonist-sensitive Ca2+ store, and is involved in the regulation of a wide range of cellular functions depending on cytosolic Ca2+. In addition, it has recently been recognized that Ca2+ regulates also processes occurring in the ER lumen, such as protein synthesis and trafficking, and cellular responses to stress. Accordingly, perturbation of ER Ca2+ homeostasis appears to be a key component in the development of several pathological situations. In this chapter, after providing an overview of the Ca2+ signaling components of the ER, we briefly summarize their role in basic pathophysiological processes and specific diseases.


Ryanodine Receptor Malignant Hyperthermia Cell Calcium Nicotinic Acid Adenine Dinucleotide Phosphate Central Core Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • György Szabadkai
  • Mounia Chami
  • Paolo Pinton
  • Rosario Rizzuto

There are no affiliations available

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