In Vitro Antileishmanial Activity of Proanthocyanidins and Related Compounds
Species of the parasitic protozoa Leishmania are estimated to threaten some 350 million people world-wide with a broad range of disease1. In their mammalian hosts, protozoa of the genus Leishmania are obligate intracellular parasites of the monocyte-macrophage system. Despite the major adverse impact of Leishmania parasites on human populations, only a few new drugs are currently on clinical trial since the introduction of the pentavalent antimonials. As part of our research program to identify novel antileishmanial compounds, we have evaluated a series of proanthocyanidins and related compounds.
KeywordsToxicity Polyphenol Catechin Epicatechin Epigallocatechin
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