Biodiversity pp 265-268 | Cite as

In Vitro Antileishmanial Activity of Proanthocyanidins and Related Compounds

  • Herbert Kolodziej
  • O. Kayser
  • A. F. Kiderlen
  • H. Ito
  • T. Hatano
  • T. Yoshida
  • L. Y. Foo

Abstract

Species of the parasitic protozoa Leishmania are estimated to threaten some 350 million people world-wide with a broad range of disease1. In their mammalian hosts, protozoa of the genus Leishmania are obligate intracellular parasites of the monocyte-macrophage system. Despite the major adverse impact of Leishmania parasites on human populations, only a few new drugs are currently on clinical trial since the introduction of the pentavalent antimonials. As part of our research program to identify novel antileishmanial compounds, we have evaluated a series of proanthocyanidins and related compounds.

Keywords

Toxicity Polyphenol Catechin Epicatechin Epigallocatechin 

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Reference

  1. 1.
    Ashford, R.W., Desjeux, P., DeRaadt, P.,1982, Parasitol. Today, 8,104CrossRefGoogle Scholar
  2. 2.
    Kayser, O., Kiderlen, A.F., Folkens, U., Kolodziej, H.,1999, Planta Medica, 65,316CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Herbert Kolodziej
    • 1
  • O. Kayser
    • 1
  • A. F. Kiderlen
    • 2
  • H. Ito
    • 3
  • T. Hatano
    • 3
  • T. Yoshida
    • 3
  • L. Y. Foo
    • 4
  1. 1.Institut für PharmaziePharmazeutische Biologie,Freie Universität BerlinBerlinGermany
  2. 2.Robert Koch-InstitutBerlinGermany
  3. 3.Faculty of Pharmaceutical SciencesOkayama UniversityOkayamaJapan
  4. 4.New Zealand Institute for Industrial ResearchLower HuttNew Zealand

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