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Biodiversity pp 265-268 | Cite as

In Vitro Antileishmanial Activity of Proanthocyanidins and Related Compounds

  • Herbert Kolodziej
  • O. Kayser
  • A. F. Kiderlen
  • H. Ito
  • T. Hatano
  • T. Yoshida
  • L. Y. Foo

Abstract

Species of the parasitic protozoa Leishmania are estimated to threaten some 350 million people world-wide with a broad range of disease1. In their mammalian hosts, protozoa of the genus Leishmania are obligate intracellular parasites of the monocyte-macrophage system. Despite the major adverse impact of Leishmania parasites on human populations, only a few new drugs are currently on clinical trial since the introduction of the pentavalent antimonials. As part of our research program to identify novel antileishmanial compounds, we have evaluated a series of proanthocyanidins and related compounds.

Keywords

Related Compound Mammalian Host Extender Unit Leishmania Parasite Antileishmanial Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

  1. 1.
    Ashford, R.W., Desjeux, P., DeRaadt, P.,1982, Parasitol. Today, 8,104CrossRefGoogle Scholar
  2. 2.
    Kayser, O., Kiderlen, A.F., Folkens, U., Kolodziej, H.,1999, Planta Medica, 65,316CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Herbert Kolodziej
    • 1
  • O. Kayser
    • 1
  • A. F. Kiderlen
    • 2
  • H. Ito
    • 3
  • T. Hatano
    • 3
  • T. Yoshida
    • 3
  • L. Y. Foo
    • 4
  1. 1.Institut für PharmaziePharmazeutische Biologie,Freie Universität BerlinBerlinGermany
  2. 2.Robert Koch-InstitutBerlinGermany
  3. 3.Faculty of Pharmaceutical SciencesOkayama UniversityOkayamaJapan
  4. 4.New Zealand Institute for Industrial ResearchLower HuttNew Zealand

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